Raws li tus tswj hwm tseem ceeb ntawm cov leeg nqaij loj hlob thiab kev loj hlob ntawm cov kab mob, GDF-8 tam sim no yog lub hom phiaj tseem ceeb rau kev kho mob pob txha pob txha, kab mob neuromuscular, rog rog, thiab mob qog noj ntshav. Scholar Rock's SRK-015 (Apitegromab) yog ib qho tshuaj sawv cev hauv pawg no. SRK-015 yog tag nrho tib neeg monoclonal antibody uas khi nrog qhov tshwj xeeb rau tib neeg Pro-GDF-8 lossis Latent GDF-8 yam tsis muaj kev khi rau cov laus GDF-8 thiab lwm yam kev loj hlob zoo sib xws yam. Nws inhibits GDF-8 ua ntej tso tawm, muab kev xaiv siab thiab muaj kev phiv tsawg. SRK-015 yog tam sim no nyob rau hauv Phase 3 kev sim tshuaj (NCT05156320) rau tus txha caj qaum atrophy (SMA) thiab yog thawj qhov muaj peev xwm kho tau cov leeg nqaij rau SMA. Roche's RO7204239 (GYM329, RG6237) lub hom phiaj Latent myostatin thiab raug kuaj rau SMA (NCT05115110) thiab facioscapulohumeral muscular dystrophy (NCT05548556).
