Peb paub tias mitochondria yog cov chaw cellular tseem mob siab rau ATP (zog) ntau lawm thiab fatty acid oxidation. Mitochondrial-Derived PeptideMOTS-ctxhawb nqa metabolic homeostasis thiab txo cov rog rog thiab insulin tsis kam. Mitochondria tseem ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab metabolic yooj.
MOTS-c hauv Osteoporosis
Osteoporosis yog ib hom kab mob ntau yam thiab muaj hnub nyoog txog cov kab mob metabolic. Pob txha mesenchymal qia hlwb (BMSCs) yog cov hlwb progenitor ntawm osteoblasts thiab adipocytes thiab ua lub luag haujlwm tseem ceeb hauv kev tsim cov pob txha.
AMPK tuaj yeem txhawb kev loj hlob, kev sib txawv thiab kev ntxhib los mos ntawm osteoblasts, uas ua haujlwm tseem ceeb hauv kev ua haujlwm ntawm tes ntawm osteoblasts.Osteoblasts yog cov hlwb uas tsim cov pob txha. Cov pob txha loj yog tswj los ntawm qhov sib npaug ntawm cov haujlwm ntawmosteoblastsuas tsim cov pob txha thiab lwm cov hlwb hu ua osteoclasts uas ua rau nws tawg.
Cov kev tshawb fawb pom tau tias BMSC tau kho nrog MOTS-c upregulated qhia theem ntawm ALP, Bglap, thiab Runx2. Qhov no ua rau tsim cov mineralized nodules, qhia lub peev xwm osteogenic ntawm BMSC's tswj los ntawm MOTS-c. Hauv cov ntsiab lus yooj yim nonscientific,
MOTS-c txhawb kev sib txawv ntawm tes ntawm BMSCs rau osteoblasts=pob txha tsim.