Tag nrho cov teebmeem tshwm sim rau SR9009 muab los ntawm REV-ERB (NR1D1, NR1D2) ua kom lub cev.
REV-ERB cuam tshuam rau tus cwj pwm circadian ntawm nas, hloov lawv cov haujlwm thiab kev pw tsaug zog [4].
Dhau li ntawm nws cov txiaj ntsig ntawm circadian atherosclerosis (kev tawm tsam ntawm BMAL1 ntau lawm), REV-ERB cuam tshuam ntau lwm yam haujlwm ntsig txog kev tsim hluav taws xob [4, 5].
REV-ERB feem ntau pom muaj nyob rau hauv daim siab, nqaij, thiab nqaij rog:
Daim siab: REV-ERB cuam tshuam rau 90% ntawm 900 cov noob nyob rau hauv circadian tswj hauv nas lub siab. Nws tua cov noob uas tsim cov piam thaj yam tsis hloov cov tshuaj insulin. Nws kuj tig rau cov noob uas tsim cov roj ntsha tshiab thiab txo cov inflammatory teb (los ntawm kev cuam tshuam rau macrophage ntau lawm) [4, 6, 7, 2].
Cov leeg: REV-ERB txhawb kev hlawv roj, ua kom cov haujlwm ntawm mitochondria, thiab txhawb cov tiam tshiab thaum txo qis kev puas tsuaj ntawm qub mitochondria [5].
Cov rog rog: REV-ERB tua cov noob lub luag haujlwm khaws cia cov rog thiab txo qis triglyceride ntau lawm [8].
Hauv kev tshawb fawb tsiaj thiab cell, SR9009:
Kev siv oxygen ntau ntxiv [8]
Kev tsim cov roj ntsha tshiab hauv lub siab poob qis [8]
Txo cov roj (cholesterol) thiab cov kua tsib acids hauv lub siab [8]
Nce tus naj npawb ntawm mitochondria hauv cov leeg [5]
Kev siv cov piam thaj thiab fatty acid ntau ntxiv hauv cov leeg [8]
Txo cov rog cia [8]
