Hauv kev noj qab nyob zoo, Tadalafil raug (AUC) nce koob-profortionally tshaj qhov koob tshuaj ntawm 2.5 txog 20 mg. Lub xeev cov ntshav ntsig txog tau tiav nyob hauv 5 hnub tom qab-txhua hnub noj tshuaj, thiab cov khoom siv tau muaj kwv yees li ntawm cov tshuaj yej ib zaug xwb. Txhais tau tias Tadalafil ntau qhov ntsuas hauv kev kawm ywj pheej tom qab kev tswj hwm ntawm 20 mg thiab ntau yam koob tshuaj ntawm 5 mg.
· Absor
Tom qab ib qho ntawm ib qho ncauj noj, cov ntshav siab tshaj plaws (CMAX) ntawm Tadalafil tau ua tiav hauv 30 feeb (nruab nrab (nruab nrab, 2 teev). Lub meej bioavailability ntawm tadalafil ua raws li kev tswj hwm ntawm qhov ncauj tsis tau txiav txim siab.
Tus nqi thiab ib txwm ntawm Tadalafil kev nqus tsis cuam tshuam los ntawm cov khoom noj; Yog li ntawd cialis tuaj yeem nqa nrog zaub mov lossis ib leeg.
Muab faib
Cov ntsiab lus tsis pom meej ntim ntawm cov chaw faib khoom tom qab faib tawm yog kwv yees li ntawm 63 l, qhia tau ntawm tadalafil rau hauv cov ntaub so ntswg. Ntawm kev kho mob ntau, 94% ntawm Tadalafil hauv ntshav yog protein protein.
Tsawg dua 0. 0005% ntawm cov tshuaj tshwm sim hauv cov phev ntawm cov ncauj lus noj qab nyob zoo.
· Metabolism
Tadalafil yog feem ntau metabolized los ntawm cyp3A4 rau nws categol metabolite. MeteCol cov metabolites loj heev methylation thiab glucuronidation mus rau m methylcatecol thiab methylcategately conjugates conjugates nkaus, feem. Cov metabolating loj me me me me me me me me methylcategl gluidonide. Methylc anaCalration yog tsawg dua 10% ntawm cov gluidonide mentalration.
Hauv cov ntaub ntawv vitro qhia tau tias cov metabolite tsis xav tias yuav tsum muaj cov tshuaj uas ua kom muaj nyob ntawm qhov ntau ntawm cov metabolite pom.
Kev saib dim
Hauv kev noj qab nyob zoo, cov kev tshem tawm ntawm Tadalafil yog 2.5 l / h / hr thiab txhais tau tias lub neej davhlau ya nyob twg yog 17,5 teev. Tadalafil yog feem ntau ua ib qho metabolite, feem ntau hauv cov quav (kwv yees li 61% ntawm cov tshuaj) thiab rau ib qho tsawg dua hauv cov zis (kwv yees li 36% ntawm cov tshuaj).
Geriatrics
Cov txiv neej noj qab haus huv cov txiv neej kawm (65 xyoo lossis tshaj saud) 25% siab dua hauv kev noj qab nyob zoo 19 txog 45 xyoos, tsis muaj kev cuam tshuam ntawm CMAX. Tsis tas yuav tsum kho cov tshuaj noj nyob ntawm lub hnub nyoog xwb. Txawm li cas los xij, cov laus laus yuav tsum tau txiav txim siab ntau rhiab rau cov tshuaj [pom siv cov neeg tshwj xeeb].
· Docyension
Cov txiv neej mob ntshav qab zib, ib qho koob tshuaj ntawm Tadalafil tau ua rau muaj kwv yees li xyoo 19% ntxiv rau hauv CMAX piv rau cov ncauj lus noj qab haus huv. Tsis muaj kev kho cov tshuaj ntau npaum li cas.
· Mob siab nrog prostatatic hyperplasia
Tsis muaj kev txheeb cais sib txawv hauv kev sib txawv (AUC thiab CMAX) tau pom ntawm cov laus (70 xyoo) thiab ntau yam ntawm 20 mg ntawm tadalafil tseem ceeb hauv kev kawm. Tsis muaj kev kho cov tshuaj ntau npaum li cas.
