Tus Kheej Tus Kheej:Igf - des yog truncated analog ntawm ib txwm muaj tshwm sim {}}} 1 (i} - 1). Tshwj xeeb, nws tsis muaj thawj peb amino acids (n {}}} {8} {proline-glutamate) pom nyob rau hauv tag nrho-ntev igf-1 molecule. Qhov kev hloov kho no tsis yog ib txwm muaj nyob hauv tib neeg.
Keeb Kwm:Nws tshwm sim los ntawm kev tshawb fawb tshawb cov qauv - kev sib raug zoo ntawm iGF-1. Cov kws tshawb fawb pom tias tshem tawm cov thawj peb cov amino acids uas kho cov peptide kev sib cuam tshuam nrog nws cov khoom siv khi.
● Qhov tseem ceeb ntawm igf-1:Tag nrho - ntev igf-1 kab mob hauv cov ntshav feem ntau (tshaj 99%) rau ib tsev neeg ntawm igf khi cov protein (igfbps). Qhov no khi ruaj khov phab spretlize igf-1 tab sis kuj tseem txo nws cov bioavailability thiab potency ntawm cov nqaij nqaij nqaij, ua yeeb yam raws li cov txheej txheem thiab kev tswj hwm txheej txheem.
● Cov "Desc" kom zoo dua (theoretical):Lub deletion ntawm thawj peb amino acids durastically txo i6 {des o} Des's Affinity rau feem ntau igfbps, tshwj xeeb yog igfbp-3, tus tsiaj loj. Qhov no theoretically tshwm sim hauv:
○ Zoo heev feem ntau feem:Qhov feem pua ntau dua ntawm iGF - des rearculates nyob rau hauv biologically nquag, tsis muaj ("pub dawb") rau iigf-1.
○ Enhanced BioFactivity:Qhov no nce feem dawb feem yog ntseeg kom txhais lus kom muaj ntau dua tus receptor ua kom zoo dua lub potency ntawm lub hom phiaj thiab cov leeg nqaij)ntawm kev puas hlwbpiv rau iGF-1. Cov kev tshawb fawb pom tias nws yuav yog 10-100 zaug ntau zogHauv vitrothiab hauv qee tus qauv tsiaj.
