Thaum xyoo 1950s, Upjohn pib muag fluoxymesterone raws li lub zog anabolic androgen steroid raws li lub npe Halotestin. Fluoxymesterone paub txog nws qhov tshwj xeeb tshaj plaws ntawm kev ua haujlwm anabolic.
Tsis ntev tom qab ntawd, Ciba Pharmaceuticals tau qhia cov tshuaj hormones rau kev ua lag luam raws li lub npe Ultandren. Txawm li cas los xij, Halotestin tseem yog tus paub zoo tshaj plaws ntawm cov neeg siv khoom.
Qhov no muaj zog anabolic steroid yog siv los kho ntau yam mob, suav nrog txiv neej tus qauv baldness, qis testosterone qib, kev puas tsuaj rau cov leeg nqaij, tshaib plab, thiab cov pob txha tawg. Tsis tas li ntawd, qhov no zoo heev anabolic steroid yog siv los kho thiab tiv thaiv androgen deficiency.
Hauv kev sib piv rau feem ntau cov tshuaj anabolic steroids, halotestin feem ntau siv rau cov txiv neej thiab poj niam. Nws txoj kev siv tau txwv me ntsis hauv lub ntiaj teb niaj hnub no, tab sis txawm li cas los xij nws tau ua haujlwm hauv kev kho mob qog noj ntshav hauv cov poj niam xaiv cov neeg mob.
Txawm hais tias nws tsis tshua muaj tshwm sim, tam sim no cov tshuaj hormones tuaj yeem siv rau hauv kev kho mob osteoporosis hauv qee cov poj niam postmenopausal. Txawm li cas los xij, nws tseem ua haujlwm raws li kev kho mob rau cov teeb meem androgen tsis txaus hauv cov neeg mob txiv neej.
Nyob rau hauv lub realm ntawm kev ua tau zoo, halotestin paub tias muaj lub koob npe nrov ntawm kev ua ib qho ntawm cov steroids uas yog ob qho tib si muaj zog tshaj plaws thiab ua qhov ceev tshaj plaws.
Nws yog ib tug hluavtaws derivative ntawm methyltestosterone. Testosterone yog niam txiv hormone (methylated testosterone). Nws tau xav tias yog lub qhov ncauj muaj zog heev anabolic steroid hormone uas tsis tuaj yeem hloov mus rau estrogen thiab muaj zog androgen siv zog heev. Tsis tas li ntawd, nws tsis tuaj yeem ua aromatized. Cov theem ntawm halotestin lub androgenic zog yog 850, whereas nws theem ntawm assimilation zog yog 1900. Piv rau cov tshuaj hormones uas nws tau muab los (testosterone) nws yog ib qho yooj yim rau txhua leej txhua tus to taub yuav ua li cas muaj zog halotestin nyob rau hauv cov nqe lus ntawm nws anabolic leeg-tsim muaj peev xwm. thiab nws muaj peev xwm tsim androgens.
Hauv kev sib piv, cov teebmeem anabolic thiab androgenic ntawm testosterone yog txhua qhov sib npaug rau 100, txawm li cas los xij, lub zog zoo kawg ntawm halotestin yog 19 npaug ntawm testosterone, thiab nws cov haujlwm androgenic yog 8.5 npaug ntawm testosterone. Vim li no, Halo yog ib qho muaj zog anabolic thiab muaj zog androgen heev. Nws muaj zog ntau dua li trenbolone, qhov muaj zog tshaj plaws uas muaj cov tshuaj anabolic steroid uas tuaj yeem yuav hauv khw muag khoom.
Cov kws kho mob tau sau halotestin rau txiv neej thiab poj niam. Nws tau raug pom los kho cov tshuaj androgen tsis txaus hauv cov txiv neej, feem ntau hu ua hypogonadism lossis andropause. FDA tau pom zoo rau kev siv Halo hauv kev kho mob uterine los ntshav tsis tu ncua hauv cov poj niam thiab mob qog noj ntshav hauv cov poj niam.
Cov npe ntawm cov kev pom zoo kho mob rau halotestin tau tsim nyob rau hauv nruab nrab -1970s thiab 1980s. FDA tau tsim ntau yam kev txwv thiab kev txwv. Nyob rau hauv xyoo tas los, cov npe ntawm cov xwm txheej uas halotestin tau pom zoo raws li kev kho mob tau txo qis kom suav nrog tsuas yog androgen tsis txaus hauv cov txiv neej, mob qog noj ntshav hauv cov poj niam, thiab, kom tsawg dua, osteoporosis hauv cov poj niam postmenopausal. Niaj hnub no, tsuas yog kev kho mob ntawm androgen tsis txaus hauv cov txiv neej thiab mob qog noj ntshav hauv cov poj niam tam sim no nyob rau hauv cov npe ntawm cov ntawv pom zoo kho mob rau halotestin. Qhov no yog vim cov npe ntawm kev pom zoo siv kho mob rau halotestin tau txwv ntxiv hnub no.
Qhov teeb meem nrog Halo yog tias nws muaj qib siab hepatotoxicity, uas zoo li yuav hloov kho cov neeg siv cov roj cholesterol profile tsis zoo. Vim tias cov teeb meem no, cov kws kho mob thiab lwm tus kws kho mob tau txiav txim siab kom tsis txhob siv halotestin rau kev kho mob uas tsis yog txiv neej androgen tsis txaus. Kev siv halotestin hauv androgen hloov kho lossis hypogonadism zoo ib yam txwv hauv TRT (testosterone hloov kho) vim tias kev tswj hwm ntawm testosterone yooj yim yog hepatotoxic tsawg dua li kev tswj hwm ntawm halotestin. Halotestin tseem yog tsim los ntawm nws cov thawj chaw tsim tshuaj paus, Upjohn, rau lub khw muag tshuaj hauv Tebchaws Meskas. Txawm li cas los xij, cov tshuaj tam sim no tau muag hauv lub npe Pharmacia.
