Yog tias koj ntsib ib qho ntawm cov hauv qab no, koj tuaj yeem yog tus neeg sib tw rau Letrozole:
Koj lub caij nyoog tsis xwm yeem, lossis koj tsis muaj sijhawm txhua.
Koj tau raug kuaj mob nrog PCOS.
Yog tias koj lub sijhawm tsis tu ncua tab sis koj cov qib progesterone qis.
Koj tab tom muaj qhov tsis tau piav qhia.
Koj tab tom kho fertility.
Yog hais tias koj yog txiv neej nrog infertility vim tsis muaj testosterone.
Letrozole Rau PCOS Cov Neeg Mob
Polycystic Ovarian Syndrome (PCOS) yog qhov tshwm sim ntau tshaj plaws ntawm anovulatory infertility[5]. 90-95% ntawm cov poj niam anovulatory nrhiav kev kho mob ntxiv lawm tshob muaj PCOS[6]. Yog li ntawd, nws ua rau kev nkag siab tias feem ntau ntawm Letrozole kev tshawb fawb tau ua rau cov neeg mob Polycystic Ovarian Syndrome.
Clomid tau siv keeb kwm los ua thawj kab kev kho mob rau cov neeg mob PCOS uas muaj teeb meem ovulatory. Txawm li cas los xij, kev tshawb fawb tsis ntev los no qhia tias Letrozole tuaj yeem tsim qhov zoo sib xws, yog tias tsis zoo, ua rau muaj kev cuam tshuam ovulation thiab ua rau muaj sia nyob rau cov neeg mob PCOS.
Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv Hauv Lub Tebchaws tau tshaj tawm txoj kev tshawb fawb hauv 2014 uas ntsuas qhov ua tau zoo ntawm Letrozole thiab Clomid los kho kev muaj menyuam tsis taus rau cov neeg mob PCOS. Thaum txoj kev tshawb no, 374 tus poj niam tau txais kev kho Letrozole, thiab 376 tus poj niam tau txais kev kho mob Clomiphene rau tsib hnub pib hnub peb ntawm lawv lub voj voog mus txog 5 lub voj voog. Ntawm 374 tus poj niam kho nrog Letrozole, 103 (27.5%) tau yug los. Ntawm 376 tus poj niam kho nrog Clomiphene, tsuas yog 72 (19.1%) ntawm cov poj niam tau yug los nyob.[7] .
Cov kws tshawb fawb los ntawm txoj kev tshawb fawb saum toj no kuj tau ntsuas seb Letrozole thiab Clomid cuam tshuam li cas ntawm ovulation rau cov neeg mob PCOS. Tsis yog tsuas yog qhov kev yug me nyuam nyob siab dua rau pawg Letrozole, tab sis yog li lawv qhov kev sib tw ovulation. Cov poj niam hauv pawg Letrozole muaj qhov sib npaug ntawm ovulation ntawm 61.7% (834 zaug hauv 1352 cycles). Cov poj niam hauv pawg clomiphene ovulated 48.3% ntawm lub sijhawm (688 zaug hauv 1425 cycles).
Txawm hais tias Letrozole tuaj yeem ua rau cov poj niam tsim ntau lub qe, qhov tshwm sim tsis zoo li cov poj niam uas muaj PCOS lossis lwm yam kab mob ovulatory. Rau cov neeg mob nrog PCOS, Letrozole tuaj yeem muab cov txiaj ntsig sib txawv me ntsis, mono-ovulation. Cov neeg mob uas muaj PCOS feem ntau yog hyper-responsive rau gonadotropin tshuaj. Ovarian hyperstimulation tshwm sim thaum tus poj niam lub zes qe menyuam o thiab xau dej rau hauv lub cev. Kev tshawb fawb luam tawm los ntawm American Society for Reproductive Medicine (ASRM) qhia tias Letrozole feem ntau yuav tsim ib qho ovulation dua li cov tshuaj Gonadtropin lossis Clomid.[8]. Letrozole tuaj yeem ua rau cov neeg mob PCOS txhim kho thiab ovulate lub qe thaum ua kom lawv muaj kev pheej hmoo qis rau hyper-stimulation, uas tuaj yeem tshwm sim los ntawm lwm cov tshuaj fertility.
Letrozole Rau Unexplained Infertility
Cov kev tshawb fawb tsis ntev los no tau pom tias Letrozole tuaj yeem muaj txiaj ntsig zoo hauv kev kho tus menyuam tsis muaj menyuam[9]. Hauv ib txoj kev tshawb fawb, cov kws tshawb fawb tau ntsuas qhov cuam tshuam ntawm Clomiphene thiab Letrozole kev kho mob ntawm kev txhim kho cev xeeb tub, tus nqi nchuav menyuam, qhov tshwm sim ntawm cov xwm txheej tsis zoo, thiab tus naj npawb ntawm cov follicles tseem ceeb rau cov neeg mob uas tsis tau piav qhia. Cov txiaj ntsig ntawm txoj kev tshawb fawb tau pom tias cov poj niam tau kho nrog Letrozole tau pom qhov muaj txiaj ntsig ntau dua ntawm kev kuaj mob cev xeeb tub piv rau cov neeg kho nrog Clomiphene. Tsis muaj qhov sib txawv ntawm cov pab pawg rau lwm cov txiaj ntsig fertility. Cov kws tshawb fawb tau xaus lus tias Letrozole tsawg kawg yog qhov zoo li Clomiphene rau kev kho cov poj niam uas tsis tau piav qhia ntxiv lawm.[10] .
Cov kws tshawb fawb tau piv qhov ua tau zoo ntawm Letrozole thiab Clomiphene kev kho mob ntawm 271 tus poj niam uas tsis tau piav qhia txog kev xeeb tub hauv kev sim randomized. Ntau tshaj ob npaug ntawm feem pua ntawm cov poj niam kho nrog Letrozole ua tiav cev xeeb tub (23.07%) piv rau cov pab pawg kho nrog Clomiphene (10.7%)[11] .
Ntxiv nrog rau qhov kev xeeb tub ntau dua, cov pab pawg kho nrog Letrozole kuj pom qhov kev txhim kho tseem ceeb hauv kev txais cov endometrial thaum ntsuas los ntawm endometrial thickness thiab lwm yam ntsuas. Cov kws tshawb fawb tau xaus lus tias Letrozole muaj txiaj ntsig zoo ntawm endometrium, uas tuaj yeem txhim kho kev cog qoob loo thiab cev xeeb tub hauv cov poj niam uas tsis tau piav qhia.[12] .
