Fragment 176-191 (AOD9604) yog ib qho me me ntawm tib neeg kev loj hlob hormone (hGH) uas qee zaum hu ua "lipolytic fragment." Fragment 176-191 khwv tau lub npe tom qab no vim qhov tseeb tias kev tshawb nrhiav lub zog tau pom tias nws txhim kho cov rog rog, tshwj xeeb tshaj yog cov nas muaj cov tshuab ua cov rog hauv khw muag khoom. Fragment 176-191 tau tshawb nrhiav ntau hauv cov tsiaj ua qauv vim tias txawm tias nws khaws cov roj-rog los ntawm hGH, nws zam dhau qee lwm yam teebmeem ntawm nws cov niam txiv protein xws li nce insulin-zoo li kev loj hlob-1 (IGF-1) qib, muaj kev cuam tshuam tsis zoo rau cov metabolism hauv cov metabolism, hloov kev hloov pauv hauv insulin, ua kom cov pob txha ntev ntev, thiab lwm yam. Lub hom phiaj cuam tshuam los ntawm tawg tsam 176-191 ua rau nws muaj txiaj ntsig zoo rau kev tshawb nrhiav tib neeg cov rog rog thiab tej zaum yuav muab lub hauv paus rau kev tsim tshuaj tiv thaiv kev rog.
HGH frag 176-191 Kev Tshawb Fawb
1. Fragment 176-191 thiab Ntshav Qab Zib
Kev tshawb fawb hauv cov tsiaj txhu tau qhia tias c-davhlau ya nyob kawg ntawm HGH yog lub luag haujlwm tseem ceeb rau cov protein lub qog ntshav qab zib (txo cov ntshav qab zib) cov teebmeem. Kev kuaj pom ntawm tsawg kawg yog rau 6 feem sib txawv tau los ntawm ntu ntu hGH no tau qhia tias muaj kev sib cais 176-191 yog qhov zoo tshaj plaws hluavtaws ua haujlwm ntawm hGH rau txo qis cov ntshav qab zib. Cov nyhuv no yog theem nrab rau kev nce qib hauv plasma insulin ntau [1]. Muaj qee qhov txaus siab siv cov fragment 176-191 los ua kev kho mob rau ob leeg mob ntshav qab zib thiab hom 2 ntshav qab zib.
2. Fragment 176-191, Cov Hluav Taws Kub Rog Thiab Rog Rog Poob
Fragment 176-191 tau txais lub npe menyuam yaus ntawm "lipolytic fragment" vim tias kev kuaj hauv cov nas tau qhia tawm cov peptide kom muaj cov rog rog loj thiab lub cev poob phaus. Nws tau xav tias qhov kev ua no los sib kho los ntawm kev nce hauv cov khoom tsim tawm ntawm beta-3 adrenergic receptors (β3-AR lossis ADRB3) [2]. Agonist kev ua ntawm ADRB3 tau paub kom ncaj qha nce cov rog hauv cov ntaub so ntswg adipose thiab kuj yog lub luag haujlwm thermogenesis hauv cov leeg pob txha [3]. Cov nas uas tau hloov pauv tau tsim tawm los ua haujlwm tsis muaj ADRB3 tsis teb rau cov teebmeem lipolytic ntawm hGH lossis tawg lossis rov qab 176-191 [2].
Cov kev tshawb fawb qhia tias kev nce rog rog ua rau cuam tshuam nrog thaj tsam ntawm 176-191 ncaj qha cuam tshuam nrog kev siv lub zog thiab yog li txo qhov hnyav, ua rau muaj qhov ze li ntawm 50% yuav txo qhov hnyav hauv cov rog rog tshaj li ntawm peb-lub lim tiam [4]. Qhov zoo siab tshaj, qhov poob phaus tshwm sim tsuas yog pom ntawm cov rog rog, nrog cov nas ntshiv tswj lub cev qhov hnyav, qhov nruab nrab, txawm tias thaum kis tau tawg ntawm 176-191 [2]. Cov kev tshawb pom no qhia tau tias muaj cov kev cai thib ob rau cov lipolysis uas ua rau ADRB3 kev ua haujlwm thaum lub cev hnyav dua lossis ze rau qhov zoo tshaj plaws, qhib thaj chaw rau kev tshawb fawb ntxiv rau lub zog homeostatsis.
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