IGF-1 LR3 (Insulin-zoo li Kev Loj Hlob Factor 1 Ntev R3) yog cov khoom siv hluavtaws, hloov kho ntawm IGF-1, ib qho tshuaj hormones tshwm sim zoo ib yam li cov qauv rau insulin. IGF-1 LR3 yog tsim los kom muaj kev ncua ib nrab-lub neej thiab txhim kho potency piv rau ntuj IGF-1, ua rau nws yog ib qho kev tshawb fawb peptide nrov rau cov leeg loj hlob, rov qab los, thiab kev tshawb fawb metabolic.
Mechanism ntawm Action:
Kev khi rau IGF-1 Receptors:
IGF-1 LR3 khi rau IGF-1 receptors ntawm cov hlwb, ua rau muaj kev cuam tshuam hauv lub cev.
Qhov no activates txoj kev zoo li covPIB 3K-AKTthiabMAPKtxoj hauv kev, uas yog qhov tseem ceeb rau kev loj hlob ntawm tes, ciaj sia taus, thiab kev loj hlob.
Nce Protein Synthesis:
Stimulates cov leeg nqaij los tsim cov proteins, ua rau kev loj hlob thiab kho.
Qhov no ua rau nws nthuav tshwj xeeb rau cov ntawv thov hauv cov leeg nqaij nkim lossis kev tshawb fawb txog kev raug mob.
Txhim kho Glucose Uptake:
Txhawb nqa cov piam thaj nkag mus rau hauv cov hlwb, txo cov ntshav qabzib thiab txhim kho cellular zog.
Inhibition ntawm Apoptosis:
Tiv thaiv cov txheej txheem cell tuag nyob rau hauv cov leeg nqaij thiab lwm yam ntaub so ntswg, pab txhawb cov ntaub so ntswg.
Kev Ua Si Ntev:
Kev hloov kho los tsim LR3 suav nrog hloov arginine ntawm txoj haujlwm 3 thiab tshem tawm IGF-binding protein-binding cheeb tsam.
Cov kev hloov no txuas ntxiv nws ib nrab-lub neej (txog 20-30 teev) thiab txo nws txoj kev sib raug zoo rau IGF-binding proteins, ua kom bioavailability.
Common Applications hauv Kev Tshawb Fawb:
Kev Loj Hlob thiab Rov Qab Los:IGF-1 LR3 tau kawm txog nws cov teebmeem anabolic ntawm cov leeg nqaij.
Kho cov ntaub so ntswg:Nws pab kho ntau yam ntaub so ntswg, nrog rau pob txha mos, tendons, thiab ligaments.
Anti-Aging Studies:Kev tshawb fawb tshawb nrhiav nws lub luag haujlwm hauv kev txhawb nqa cell rov tsim dua tshiab thiab txo cov cim ntawm kev laus.
Glucose Metabolism:Cov kev tshawb fawb tshawb xyuas nws lub peev xwm los tswj cov ntshav qab zib hauv kev tshawb fawb ntshav qab zib.
