Tus Kheej Tus Kheej:Gonadorelin yog ib tug decapeide (10 amino acids) zoo ib yam rau endogenous gnrh tsim los ntawm hypothalamus hauv lub hlwb.
Thawj txoj haujlwm:Nws lub luag haujlwm ntawm lub luag haujlwm yog txhawm rau txhawb lub caj pas pwjmom.
● Mechanism:Thaum los khi rau cov khoom siv tshwj xeeb ntawm cov qog nqaij tawv gonadotrophin tau, gonadorelin ua synthesis thiab pulsatile tso ob qho tseem ceeb gonadotropins:
○ Lutinizing Hormone (LH):Cov ntsiab lus ncaj qha rau Leydig hlwb hauv cov kev xeem los tsim thiab tso tawmTesitaTosterone.
○ Cov neeg hauv paus - stimulating hormone (FSH):Qhov feem ntau txhawb cov phevategogenesis (phev ntau lawm) hauv kev sim thiab kev txhim kho hauv zes qe menyuam.
● Cov Pontatility Paradox:Qhov tseeb, tuslub ntujKev tso zais ntawm GNRH yogMob heev pulsilileCov. Kev nkag mus tsis ntev los yog exogenous dosing (zoo li loj 2mg txhaj tshuaj) paradoxicallyDownregulatesGnrh receptor rhiab thiabtxhawbGonadotropin tso tawm. Qhov no yog qhov fab ntxeev ntawm cov nyhuv xav tau thiab qhov tsis txaus ntseeg uas muaj kev siv tsis zoo.
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