SR9009 yog dab tsi

SR9009 yog ib feem hu ua REV-ErbA agonist. Hais lus nruj me ntsis, nws tsis yog SARM, tab sis TA feem ntau tuaj yeem siv ua ke nrog SARM, yog li TA kuj tau muab faib rau hauv qeb SARM.

Zoo li txhua yam SARMs, SR9009 tsis muaj estrogenic phiv thiab tsis muaj lub siab toxicity. Nws tuaj yeem sib npaug cov qib roj cholesterol hauv lub cev, txo cov rog, thiab txhim kho cov metabolism hauv basal txhawm rau txhim kho kev tawm dag zog thiab muaj peev xwm hlawv rog.

SR9009 yog Rev-ErbA activator tsim los ntawm xibfwb Thomas Burris ntawm Scripps Research Institute. Nws luam tawm nws qhov kev tshawb pom thawj zaug hauv phau ntawv Journal Nature Medicine, qhia tias kev ntxiv nrog SR9009 pab txo qhov hnyav, ua kom lub cev muaj zog thiab lub zog, thaum txo qis cov roj cholesterol hauv cov ntshav, txo qhov mob thiab kev pheej hmoo ntawm kab mob plawv. pheej hmoo. xibfwb Burris txoj kev tshawb fawb pom tias txawm tias tsis muaj kev tawm dag zog, ntxiv nrog SR9009 nce cov metabolism hauv cov leeg pob txha los ntawm 50%. Txawm tias thaum sedentary, tus neeg siv tsim cov leeg zoo li tus neeg ncaws pob hauv kev cob qhia. Thaum tsis muaj kev tawm dag zog, kev siv SR9009 tuaj yeem ua rau cov metabolism hauv basal.

Ntxiv nrog rau SR9009 pib ua cov txheej txheem hauv lub cev los ntawm kev ua kom cov protein Rev-Erb. Hauv particular, SR9009 tuaj yeem txhawb kev tsim cov mitochondria hauv cov leeg nqaij, thiab txhawb kev txhim kho cov metabolism, cov leeg nqaij thiab lub zog. Kev khiav ceev ntawm kev sim nas muab Sr9009 nce 50%. SR9009 kuj tseem tuaj yeem ua kom muaj rog rog thiab txo cov rog rog los ntawm kev nce tus neeg metabolic tus nqi.

SR9009 kuj tseem tuaj yeem muab lwm cov txiaj ntsig kho mob. Cov kev tshawb fawb tsis ntev los no tau pom tias kev noj tshuaj txhua hnub ntawm Sr-900 tuaj yeem txo cov ntshav plasma triglycerides los ntawm 12%, tag nrho cov roj cholesterol los ntawm 47%, plasma non-esterified fatty acids los ntawm 23%, plasma qabzib los ntawm 19%, thiab plasma insulin qib los ntawm 35. %. Pro-inflammatory cytokines raug txo los ntawm 72%.

SR9009 kuj muaj ntau yam zoo ib yam li Gw-501516. Qhov tseeb, ob qho tib si feem ntau siv ua ke. Qhov sib txawv tseem ceeb ntawm ob lub tebchaw no yog lawv ib nrab-lub neej, Gw-501516 muaj ib nrab-lub neej ntawm 24 teev, thaum SR9009 muaj ib nrab-lub neej tsuas yog 4 teev. Vim nws luv luv ib nrab-lub neej, SR9009 yog zoo tagnrho rau pre-workout supplementation. Nyob rau tib lub sijhawm, SR9009 yog cov rog-soluble, yog li nws raug pom zoo kom haus nws nrog zaub mov (xws li noj mov ua ntej) kom tau txais txiaj ntsig zoo dua.

Cov koob tshuaj pom zoo yog tib yam rau cov txiv neej thiab poj niam. Yog tias siv SR9009 ib leeg, qhov pom zoo noj txhua hnub yog 10mg * 3 zaug, thiab lub sijhawm noj yuav tsum tau sib kis kom deb li deb tau. Qhov yooj yim tshaj plaws los ua qhov no yog noj 10 mg nrog pluas tshais, pluas su thiab noj hmo. Yog tias kev sib xyaw ua ke ntawm SR9009 thiab Gw-501516 siv, ces koj tuaj yeem xaiv noj 20 mg ntawm Gw-501516 nrog pluas tshais thiab 10 mg ntawm SR9009 nrog rau pluas noj ua ntej kev cob qhia.