Melanotan 2 yog dab tsi?
Melanotan 2 Tanning Injections (lwm lub npe hu ua MT2) yog thawj zaug ua ke ntawm University of Arizona. Kev tshawb fawb muaj paub tias onc ntawm qhov zoo tshaj plaws tiv thaiv kab mob cancer ntawm daim tawv nqaij yog melanin activated nyob rau hauv daim tawv nqaij, tan. Lawv tau xav tias txoj hauv kev zoo los txo cov qog nqaij hlav qog nqaij hlav hauv tib neeg yuav yog los txhawb lub cev lub cev pigmentary los tsim kev tiv thaiv tan ua ntej raug UV. Lub cev qhov tshwm sim ntawm cov tshuaj hormones MSH ua rau melanogenesis, uas yog txheej txheem ntawm cov tawv nqaij pigment hlwb (melanocytes) tsim cov tawv nqaij pigment (melanin). Lawv tau sim kom pom tias kev tswj hwm cov tshuaj endogenous no rau lub cev ncaj qha tuaj yeem yog txoj hauv kev zoo los ua kom tsis muaj hnub ci. Dab tsi lawv pom yog tias thaum nws tshwm sim ua haujlwm, ntuj MSH tau luv luv ib nrab ntawm lub neej hauv lub cev kom ua tau raws li cov tshuaj kho mob. Yog li ntawd lawv txiav txim siab mus nrhiav tau ib qho kev muaj zog thiab ruaj khov, ib qho uas yuav ua tau ntau dua.
Tom qab kev sib txuas thiab tshuaj xyuas ntau pua ntawm cov molecules, cov kws tshawb fawb tau coj los ntawm Victor J. Hruby thiab Mac E. Hadley, pom peptide, [Nle4, D-Phe7] MSH, uas yog kwv yees li 1,000 lub sij hawm muaj zog tshaj qhov Natural MSH. Lawv dubbed no peptide molecule tshiab, "Melanotan" (tom qab Melanotan -1, tam sim no paub li afamelanotide). Tom qab ntawd lawv tau tsim lwm qhov analog, Ac-Nle-cyclo [Asp-His-D-Phe-Arg-Trp-Lys]-NH2), uas lawv hu ua "Melanotan" Tanning Txhaj. Cov kws tshawb fawb tau cia siab tias yuav siv cov peptides no los tawm tsam melanoma los ntawm kev txhawb nqa lub cev lub cev pigmentary mechanism los tsim kom muaj xim tawv nqaij yam tsis tas yuav tsum raug cuam tshuam rau theem teeb meem ntawm UV hluav taws xob. Qhov no nyob rau hauv lem, lawv xav hais tias, yuav txo tau lub peev xwm ntawm daim tawv nqaij puas tsuaj uas nws thiaj li ua rau mob cancer ntawm daim tawv nqaij.
Ib theem pib kuv qhov kev sim tshuaj ntsuam xyuas tau ua rau peb tus txiv neej los ntawm College of Medacine, Pharmacology Department, University of Arizona hauv Tuscon, Arizona pulished hauv 1996 tau tshaj tawm tias, "Melanotan" Tanning Txhaj Tshuaj muaj tanning kev ua rau tib neeg tsuas yog 5 koob tshuaj qis txhua hnub. los ntawm kev txhaj tshuaj subcutaneous." Cov kev mob tshwm sim tau tshaj tawm yog xeev siab me ntsis thiab "stretching thiab yawning complex" uas cuam tshuam nrog kev ua haujlwm ntawm lub raum caj pas.
Lub Department of Pharmacology, University of Arizona College of Medacin tau luam tawm xyoo 1998 uas koom nrog 10 cov txiv neej uas raug kev txom nyem los ntawm kev puas siab puas ntsws erectile kawg. Lawv qhov kev sim tau xaus lus tias, "Melanotan" Tanning Txhaj yog lub zog pib ntawm erections hauv cov txiv neej nrog pyschogenic erectile dydfunction thiab muaj peev xwm tswj tau cov kev mob tshwm sim ntawm koob tshuaj 0.025mg / kg.
Ib txoj kev tshawb fawb soj ntsuam luam tawm xyoo 2000 ntawm 20 tus txiv neej uas muaj kev puas siab puas ntsws thiab cov organic erectile kawg tau ua nyob rau hauv Section of Urology ntawm University of Arizona College of Medacin xaus lus, "thaum Melanotan II Tanning Txhaj yog lub zog pib ntawm penile erection rau cov txiv neej nrog ecrectile dysfunction.
Kev piav qhia
MT-2 (los yog Melanotan II) yog lwm cov peptide hluavtaws ntawm cov tshuaj hormones xwm thiab lactam cyclic analog ntawm melanocortin protein hormone alpha-melanocyte stimulating hormone; Nws molecular hnyav / hnyav yog 1024.2 nrog molecular mis yog C50H69N15O9. Cov analogue no muaj cov yam ntxwv ntawm cov proteins. Melanotan II tau lub hom phiaj tsim nyob rau xyoo 1991 los ntawm Asmeskas cov kws tshawb fawb los ntawm Arizona nyob rau hauv kev coj noj coj ua ntawm Hruby / Hedley, thaum lawv tab tom nrhiav kom ruaj khov thiab muaj zog hloov pauv ntawm primal MSH. Tom qab ntawd ntau cov kev tshawb fawb soj ntsuam tau koom nrog ntau lub teb chaws los txheeb xyuas qhov ua tau zoo ntawm peptide tshiab.
Zoo li nws cov thawj, Melanotan I, MT-2 plays lub luag hauj lwm hauv stimulating melanogenesis thiab los ntawm qhov uas muab kev tiv thaiv mechanism tiv thaiv UV rays txij li thaum nyob rau hauv nws cov yeeb yam melanocytes muaj peev xwm ua kom ntau lawm thiab tso tawm ntawm cov tshuaj hormone melanin uas kuj yog hom peptides. Txawm li cas los xij, cov kws tshawb fawb tseem tuaj yeem pom lwm tus yam ntxwv ntawm qhov kev tshawb fawb no uas yog qee yam tshuaj aphrodisiac. Nws kuj tseem muaj cov txiaj ntsig zoo ntawm cov rog-mobilizing.
Txhua yam kev xav tau, thov hu rau kuv
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