Follistatin 344 thiab cov leeg loj hlob
Follistatin ua haujlwm los ntawm kev khi rau thiab inhibiting transforming growth factor- (TGF-) peptides xws li myostatin uas yog lub luag haujlwm rau kev tswj thiab txo cov leeg nqaij. Nws tseem tsim nyog taw qhia tias myostatin tuaj yeem muaj lub luag haujlwm tswj hwm hauv pob txha pob txha fibrosis; Myostatin ntau dhau tuaj yeem ua rau cov ntaub so ntswg ua haujlwm tsis zoo thiab ua rau muaj kab mob ntev hauv cov kabmob tseem ceeb, cov ntaub so ntswg, thiab cov pob txha pob txha.
Ntxiv rau kev tiv thaiv cov khoom degenerative ntawm myostatin, follistatin tseem inhibits pituitary gland synthesis thiab tso tawm ntawm follicle-stimulating hormone (FSH). Qib FSH siab hauv cov txiv neej yuav qhia tau tias cov noob qes ua haujlwm tsis raug; Tus mob no txwv cov nqaij ntshiv loj hlob, rov qab, thiab ua haujlwm hormonal ib txwm. Txawm li cas los xij, FSH qib uas qis dhau kuj tuaj yeem cuam tshuam kev noj qab haus huv thiab kev muaj peev xwm ntawm kev ua me nyuam.
Txawm li cas los xij, qee qhov myostatin inhibitors zoo li Trichostatin A (TSA) xav tau kev tswj hwm txhua hnub, nce qib ntawm FS344 tau pom txog li 15 lub hlis tom qab pib txhaj tshuaj.Qhov tsis xav tau kev tswj hwm txhua hnub ua rau follistatin ib qho kev ntxim nyiam rau kev tiv thaiv myostatin.
Kev nce siab tsis ntev los no hauv zej zog kev tshawb fawb ntawm follistatin thiab lwm yam myostatin inhibitors feem ntau yog vim muaj kev xav nrhiav lwm txoj hauv kev los kho cov leeg mob; Qhov kev xaiv nrov tshaj plaws tam sim no yog androgen steroids uas ua rau muaj ntau yam kev mob tshwm sim thiab kev pheej hmoo rau kev noj qab haus huv mus ntev.
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