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Kev piav qhia
Delta pw tsaug zog-inducing peptide (DSIP) yog ib yam khoom tshwm sim, uas yog thawj zaug cais tawm ntawm luav hlwb hauv xyoo 1977. Cov khoom xav paub no yog nonapeptide uas ib txwm ua rau hauv hypothalamus thiab tsom ntau qhov chaw suav nrog qee qhov hauv lub hlwb. Raws li nws lub npe qhia DSIP txhawb kev pw tsaug zog thiab qhov no tau tshwm sim hauv luav, nas, nas, miv thiab tib neeg.
Qhov tseeb DSIP txhawb nqa ib hom kev pw tsaug zog uas yog tus cwj pwm los ntawm kev nce hauv delta atherosclerosis ntawm EEG.DSIP ib txwm muaj nyob rau hauv feeb hauv cov ntshav. Lub hlwb thiab cov ntshav plasma DSIP cov concentrations pom qhov txawv txav ntawm lub hnub nyoog thiab tau pom tias muaj kev sib raug zoo ntawm DSIP plasma concentrations thiab circadian atherosclerosis hauv tib neeg. Concentrations tsawg thaum sawv ntxov thiab siab dua nyob rau yav tav su.
Kev nce siab ntawm endogenous DSIP concentration tau pom tias muaj feem cuam tshuam nrog kev cuam tshuam ntawm ob qho tib si qeeb-yoj pw tsaug zog thiab nrawm-tawm-kev pw tsaug zog thiab nthuav dav nrog lub cev kub. Plasma concentrations ntawm DSIP yog in¯uenced los ntawm kev pib pw tsaug zog. Cov neeg mob uas muaj Cushing's syndrome raug kev txom nyem los ntawm qhov tsis muaj kev pw tsaug zog qeeb tab sis qhov sib txawv ntawm lub diurnal nyob rau hauv qeeb-yoj thiab ceev-qhov muag-ceev pw tsaug zog hauv cov neeg mob zoo li zoo li cov neeg mob ib txwm muaj.
Thaum piv nrog rau feem ntau lwm cov peptides, DSIP yog qhov txawv ntawm qhov uas nws tuaj yeem hla cov ntshav ± lub hlwb tsis zoo thiab nkag tau yooj yim los ntawm lub plab yam tsis tau denatured los ntawm cov enzymes.DSIP yog tam sim no nyob rau hauv cov concentration ntawm tib neeg cov mis nyuj (10 ± 30 ng mL. ± 1). Txhua tus niam uas pub niam mis rau nws cov menyuam yuav ua pov thawj tias muaj peev xwm pub mis rau pw tsaug zog. Txawm li cas los xij, kev pub mis ntawm arti®cial tej zaum yuav muaj cov txiaj ntsig zoo sib xws, thiab nws tsis paub tias DSIP cov ntsiab lus muaj feem cuam tshuam rau lub voj voog pw tsaug zog hauv tib neeg neonates.
DSIP tau raug tsim los. Kev tswj hwm ntawm cov khoom siv hluavtaws tsis ua rau kev ua siab ntev .DSIP tuaj yeem soj ntsuam los ntawm ntau cov txheej txheem xws li xov tooj cua immunoassay (RIA), enzyme immunoassay thiab kev ua haujlwm siab ua kua chromatography nrog RIA.
DSIP muaj ib nrab-lub neej nyob rau hauv tib neeg plasma ntawm 7 thiab 8 min. Nws yog degraded nyob rau hauv cov ntshav, txoj kev uas muaj cov amino-peptidases. Yog li ntawd, kev sib cuam tshuam tshuaj muaj peev xwm tuaj yeem pom ntawm DSIP thiab cov tshuaj uas inhibit lossis lawv tus kheej metabolized los ntawm peptidases. Captopril yog ib tus neeg sawv cev zoo li no thiab cov neeg mob tam sim no tab tom kho nrog ib qho ntawm cov angiotensin-hloov enzyme inhibitors yuav tsum tau raug cais tawm ntawm DSIP kev kho mob raws tu qauv kom txog thaum muaj kev tshawb fawb ntxiv.
Cov txiaj ntsig kev noj qab haus huv ntawm DSIP Peptides
Tswj cov qauv pw tsaug zog
Qhov txiaj ntsig tseem ceeb tshaj plaws ntawm DSIP yog nws qhov cuam tshuam rau kev tswj hwm ntawm kev pw tsaug zog rau tib neeg. Tom qab qhov kev tshawb pom thawj zaug ntawm peptide no, ntau cov kev tshawb fawb tau ua raws li tsuas yog sim cov lus pom zoo: "DSIP tej zaum yuav yog qhov tseem ceeb ntawm kev pw tsaug zog endogenous." Cov ntawv ceeb toom ntxiv tau tawm hais txog qhov nce ntawm kev pw tsaug zog ua rau tib neeg raug txhaj tshuaj me me. Lwm cov kev tshawb fawb kuj pom tias nws muaj peev xwm ua rau delta-yoj pw tsaug zog. Lawv tau coj mus rau qhov kev ntsuam xyuas yav tom ntej ntawm DSIP, tshwj xeeb ntawm qhov ua tau tias nws tuaj yeem yog kev kho mob zoo rau insomnia.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias DSIP tsis raug nquahu kom siv los ua lwm txoj hauv kev sedatives. Tsis tas li ntawd, cov txiaj ntsig uas ua rau muaj txiaj ntsig zoo ntawm DSIP koom nrog cov neeg uas raug kev txom nyem los ntawm kev pw tsaug zog. Cov neeg noj qab haus huv uas tsis muaj kev tsis txaus siab txog kev cuam tshuam circadian atherosclerosis tau txais txiaj ntsig tsawg kawg nkaus. Txawm li cas los xij, kev kho kom rov zoo tag nrho ntawm lub circadian atherosclerosis tseem yog qhov tseem ceeb rau kev tshawb fawb soj ntsuam ntau ntxiv.
Regulates secretion ntawm ACTH thiab LH Hormones
DSIP kuj tseem cuam tshuam nrog kev tso tawm ntawm Adrenocorticotropic Hormone (ACTH). Nrog rau kev noj qab haus huv circadian atherosclerosis, ACTH ua raws li cov txheej txheem ntawm kev nyob rau theem siab thaum sawv ntxov (ib txwm theem), maj mam txo qis thaum nruab hnub, thiab mus txog qib qis tshaj thaum hmo ntuj. Qee qhov kev tshawb fawb pom tau tias DSIP txo qis ACTH qib, yog li txhawb kev pw tsaug zog ntawm lub cev.
Cov peptide no kuj txhawb kev tso tawm ntawm Luteinizing Hormone (LH) qib. Cov kev cai no pab txhawb kev inhibition ntawm somatostatin, kev loj hlob hormone-inhibiting hormone (GHIH).
Analgesic Rau Mob Mob
DSIP peptide muaj lwm yam khoom tsis sib xws uas yuav muaj txiaj ntsig zoo rau kev kho mob ntev. Piv txwv li, qee qhov kev tshawb fawb qhia tias nws cuam tshuam rau qhov txo qis ntawm amphetamine-induced hyperthermia.
"Tus neeg sawv cev tau siv rau kev kho mob cawv thiab tshem tawm opioid nrog qee qhov ua tiav. Cov tsos mob thiab cov tsos mob ploj mus tom qab txhaj tshuaj DSIP, txawm hais tias qee cov neeg mob tau qhia tias mob taub hau qee zaus. (Pollard & Pomfrett, 2001)"
Normalizes ntshav siab
Ntxiv mus, DSIP kuj elicits antihypertensive teebmeem.
Ib txoj kev tshawb fawb ntawm spontaneously hypertensive nas (SHR) ntsuas tias tsis pub dhau kaum hnub ntawm DSIP infusion, nws ua rau kev saib xyuas ntshav siab ntawm ib theem.
Cov lus pom zoo
Muaj kev phiv tshwm sim ntawm kev siv sijhawm luv lossis ntev ntawm DSIP peptides. Txawm li cas los xij, tsis muaj qhov cuam tshuam loj heev txog tam sim no tau tshaj tawm nrog kev siv DSIP, tsis hais rau tsiaj lossis tib neeg. Txawm li cas los xij, nws yog qhov pom zoo kom sab laj nrog koj tus kws kho mob ua ntej noj cov khoom peptide.
Lwm Cov Kev Siv Rau DSIP
Ntxiv rau qhov nws muaj peev xwm cuam tshuam txog kev pw tsaug zog, DSIP kuj tau kawm txog ntau yam ntawm lwm yam kev siv vim nws muaj peev xwm cuam tshuam nrog neurotransmitters xws li dopamine thiab serotonin.
● DSIP kuj tseem siv tau rau:
● Kev ua haujlwm tiv thaiv kab mob
●Antioxidant thiab anti-inflammatory zog
● Kev ntxhov siab thiab kev nyuaj siab
● Kev tswj mob
● Ntshav siab
● tswj circadian atherosclerosis
Txawm hais tias nws feem ntau suav tias muaj kev nyab xeeb thaum noj cov tshuaj tsawg, DSIP tsuas yog yuav tsum tau siv nrog kev taw qhia ntawm tus kws kho mob uas tsim nyog.
Cov peptide no tseem tab tom tshawb fawb kom nkag siab txog nws qhov muaj peev xwm cuam tshuam txog kev pw tsaug zog thiab kev ntxhov siab, nrog rau nws cov kev mob tshwm sim thiab kev cuam tshuam ntawm cov tshuaj.
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Delta Pw tsaug zog Inducing Factor yog dab tsi?
Delta pw tsaug zog-inducing factor (DSIF) yog ib qho protein complex uas ua lub luag haujlwm hauv kev tswj hwm ntawm noob caj noob ces, tshwj xeeb tshaj yog thaum lub sijhawm hloov pauv, uas yog thawj kauj ruam hauv kev sib txuas ntawm RNA los ntawm DNA. DSIF tseem hu ua DRB rhiab heev-inducing factor (DSIF) los yog 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) rhiab heev-inducing factor.
DSIF yog tsim los ntawm ob subunits: SPT4 (Suppressor ntawm Ty 4) thiab SPT5 (Suppressor ntawm Ty 5). Nws tau xub pom nyob rau hauv cov poov xab, qhov twg nws tau pom tias muaj kev koom tes hauv kev tswj cov elongation ntawm RNA polymerase II (RNAPII) thaum lub sij hawm transcription. RNAPII yog lub enzyme lub luag haujlwm rau transcribing protein-coding noob rau hauv tub txib RNA (mRNA).
DSIF ua raws li tus tswj hwm ntawm kev hloov pauv elongation los ntawm kev tswj tus nqi uas RNAPII txav raws DNA qauv strand. Nws tuaj yeem txhawb lossis inhibit transcription elongation, nyob ntawm seb nws cuam tshuam nrog lwm yam. Thaum DSIF cuam tshuam nrog lwm cov proteins xws li NELF (Negative Elongation Factor), nws tuaj yeem ua rau ncua ntawm RNAPII thiab inhibit transcription elongation. Txawm li cas los xij, thaum DSIF cuam tshuam nrog cov txiaj ntsig zoo elongation, nws tuaj yeem txhawb nqa kev hloov pauv tau zoo.
DSIF lub luag haujlwm hauv kev tswj hwm kev hloov pauv yog qhov tseem ceeb rau kev qhia cov noob caj noob ces, thiab nws cov haujlwm tuaj yeem cuam tshuam los ntawm ntau yam kev taw qhia thiab cov xwm txheej hauv lub cell. Kev ua haujlwm tsis zoo ntawm DSIF tuaj yeem ua rau muaj qhov tshwm sim tseem ceeb ntawm cov noob qhia thiab cov txheej txheem ntawm tes, thiab nws tau kawm nyob rau hauv cov ntsiab lus ntawm ntau yam kab mob thiab mob, nrog rau kev mob qog noj ntshav thiab kab mob HIV.
Ntim & Xa khoom:
1. Pab neeg tshaj lij rau pob thiab xa khoom xa tuaj.Tshwj xeeb txoj kev xa khoom 100grams rau 100kg hmoov ib zaug rau koj lub tebchaws.
2. Kev xa khoom sai thiab ceev ceev tuaj yeem npaj rau kev lis kev cai dhau Guaranteed.
3. Taug qab code 24 teev rau kev lis kev cai dhau lav.
4. Ntau yam khoom xa tuaj, kuj tuaj yeem ua raws li qhov koj xav tau.Txhua yam kev xav tau, thov hu rau kuv
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