GDF-8 CAS 901758-09-6

Khoom Paub meej:

Nqe lus piav qhia:

Myostatin (tseem hu ua kev loj hlob sib txawv ntawm 8, luv luv GDF-8) yog myokine, ib qho protein uas tsim tawm thiab tso tawm los ntawm myocytes uas ua rau cov leeg hlwb 'autocrine muaj nuj nqi los tiv thaiv myogenesis: nqaij cell loj hlob thiab sib txawv. Hauv tib neeg nws yog encoded los ntawm MSTN noob. Myostatin yog ib qho secreted kev loj hlob sib txawv yam uas yog ib tug tswv cuab ntawm TGF beta protein tsev neeg.

Tsiaj txhu tsis muaj myostatin lossis kho nrog cov tshuaj uas thaiv cov haujlwm ntawm myostatin muaj cov leeg nqaij ntau. Tsis tas li ntawd, cov tib neeg uas muaj kev hloov pauv hauv ob daim ntawv theej ntawm myostatin gene muaj ntau cov leeg nqaij thiab muaj zog dua li qub. Kev thaiv cov kev ua ntawm myostatin tuaj yeem muaj kev kho mob hauv kev kho cov nqaij ntshiv cov kab mob xws li cov leeg nqaij dystrophy.

GDF-8 (propeptide-Fc) yog ib qho kev loj hlob ntawm cov leeg nqaij inhibitory kev loj hlob thiab kev loj hlob ntawm cov leeg nqaij. Cov leeg nqaij inhibin yog tam sim no nyob rau hauv cov txheej txheem kho ntawm cov leeg, thiab nws qhov xwm txheej yog inhibition ntawm muscleogenesis (cov leeg nqaij tsim txheej txheem). Cov kws tshawb fawb tau tshawb nrhiav ib txoj hauv kev tshiab los txhim kho kev kho thiab rov tsim kho cov leeg nqaij thiab pob txha hauv qee qhov mob los ntawm kev qhia txog cov recombinant myostatin peptides los ntawm cov nqaij pob txha tshiab.

Myostatin / GDF-8 is a protein that in humans is encoded by the MSTN gene. It isproduced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70 feem pua) ntawm myostatin nyob rau hauv cov ntshav khi rau nws cov propeptide ua tus tswj tsis zoo ntawm myostatin. Recombinant human Myostatin Propeptide yog cov protein uas tsis yog glycosylated, muaj 244 amino acids, nrog rau qhov hnyav molecular ntawm 27.8 kDa. Peb Myostatin 1mg Tagged. Cov cim npe yog chains / pawg ntawm cov amino acids / proteins, nws yog txawv teb chaws protein uas yuav ua rau cov tshuaj tiv thaiv kab mob hauv feem ntau.

Myostatin / GDF{{0}} yog ib tug tswv cuab ntawm TGF beta superfamily ntawm cov proteins. Tib neeg myostatin muaj ob lub subunits zoo tib yam, txhua tus muaj 109 amino acid residues. Nws tag nrho molecular hnyav yog 25.0 kDa. Cov protein yog tsim nyob rau hauv daim ntawv tsis muaj zog. Rau nws kom qhib tau, ib tug protease cleaves NH2-terminal, los yog "pro-domain" feem ntawm lub molecule, uas ua rau tam sim no-active COOH-terminal dimer

Myostatin (GDF-8) yog ib tug tswv cuab ntawm kev hloov pauv kev loj hlob-beta (TGF-beta) superfamily uas tau nthuav tawm hauv cov leeg pob txha, thiab myostatin poob-ntawm-ua haujlwm ua rau ob npaug ntawm cov leeg pob txha. Cov nas uas tsis muaj Myostatin tau siv los ua tus qauv rau kev kawm txog kev sib cuam tshuam ntawm cov leeg-pob txha, thiab ntawm no peb tshuaj xyuas cov skeletal phenotype cuam tshuam nrog kev hloov pauv myostatin signaling. Nws yog tam sim no paub tias myostatin yog ib qho tseem ceeb regulator ntawm mesenchymal qia cell proliferation thiab sib txawv, thiab nas tsis muaj myostatin gene qhia txo lub cev rog thiab ib tug generalized nce nyob rau hauv cov pob txha ceev thiab lub zog.

Kev nce hauv cov pob txha ceev tau pom nyob rau hauv feem ntau thaj chaw anatomical, nrog rau cov ceg, txha nraub qaum, thiab lub puab tsaig, thiab myostatin inhibitors tau pom tias yuav ua rau cov pob txha loj tuaj. Myostatin kuj tau qhia nyob rau hauv cov theem thaum ntxov ntawm pob txha kho, thiab myostatin tsis muaj peev xwm ua rau kom pob txha callus loj thiab lub zog. Ua ke, cov ntaub ntawv no qhia tias myostatin muaj kev cuam tshuam ncaj qha rau kev loj hlob thiab kev sib txawv ntawm cov hlwb osteoprogenitor, thiab tias myostatin antagonists thiab inhibitors yuav ua kom cov leeg nqaij thiab pob txha muaj zog.

Daim ntawv thov:

1. Kho cov leeg nqaij atrophy, ntxiv dag zog rau cov leeg toughness, nce cov leeg nqaij.

2. Kev kho cov neeg mob tsis noj zaub mov zoo yog qhov ntsuas tseem ceeb ntawm kev cob qhia cov neeg ncaws pob.

3. GDF-8 tuaj yeem tiv thaiv qhov nce ntxiv vim muaj hnub nyoog nce cov ntaub so ntswg adipose, thiab txo qhov tshwm sim ntawm ntshav qab zib.

Cov noob encoding myostatin tau pom nyob rau hauv 1997 los ntawm geneticists Se-Jin Lee thiab Alexandra McPherron uas tsim ib hom nas mutant uas tsis muaj cov noob. Cov nas no myostatin "knockout" muaj kwv yees li ob zaug cov leeg nqaij ib txwm muaj. Cov nas no tom qab hu ua "cov nas muaj zog".

Qhov tshwm sim tsis zoo ntawm myostatin tau txheeb xyuas hauv cov nyuj los ntawm Ravi Kambadur, whippings, thiab tib neeg; nyob rau hauv txhua rooj plaub, qhov tshwm sim yog ib qho kev nce hauv cov leeg nqaij. Kev hloov pauv hauv 3 'UTR ntawm myostatin gene hauv Texel yaj tsim lub hom phiaj chaw rau microRNAs miR-1 thiab miR-206. Qhov no yuav ua rau cov leeg nqaij phenotype ntawm no yug yaj.

Tib neeg myostatin muaj ob lub subunits zoo tib yam, txhua qhov muaj 109 (NCBI database lees tias tib neeg myostatin yog 375 residues ntev) amino acid residues. Nws tag nrho molecular hnyav yog 25.0 kDa. Cov protein tsis ua haujlwm kom txog thaum lub protease cleaves NH2-terminal, los yog "pro-domain" feem ntawm cov molecule, ua rau lub active COOH-terminal dimer. Myostatin khi rau activin hom II receptor, ua rau muaj kev nrhiav neeg ua haujlwm ntawm coreceptor Alk-3 lossis Alk-4. Qhov no coreceptor ces pib lub cell signaling cascade nyob rau hauv cov leeg, uas muaj xws li ua kom cov transcription yam nyob rau hauv SMAD tsev neeg - SMAD2 thiab SMAD3. Cov xwm txheej no tom qab ntawd ua rau muaj kev tswj hwm cov noob caj ces myostatin. Thaum siv rau myoblasts, myostatin inhibits lawv qhov sib txawv rau hauv cov leeg nqaij laus. myostatin muaj kev cuam tshuam ncaj qha rau kev loj hlob thiab kev sib txawv ntawm cov hlwb osteoprogenitor, thiab tias myostatin antagonists thiab inhibitors zoo li yuav txhim kho cov leeg nqaij thiab pob txha.

Myostatin (GDF-8), tus tswv cuab ntawm TGFbeta superfamily, yog lub zog thiab tshwj xeeb tsis zoo ntawm cov leeg pob txha pob txha. Nyob rau hauv cov ntshav, myostatin circulates raws li ib feem ntawm ib tug latent complex uas muaj myostatin propeptide thiab follistatin-relatedgene.

The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70 feem pua) ntawm myostatin nyob rau hauv cov ntshav khi rau nws cov propeptide. Lub myostatin propeptide yog qhov tsis zoo regulator ntawm myostatin hauv vivo.

Tsiaj txhu tsis muaj myostatin lossis kho nrog cov tshuaj uas thaiv cov haujlwm ntawm myostatin muaj cov leeg nqaij ntau. Tsis tas li ntawd, cov tib neeg uas muaj kev hloov pauv hauv ob daim ntawv theej ntawm myostatin gene muaj ntau cov leeg nqaij thiab muaj zog dua li qub. Kev thaiv cov kev ua ntawm myostatin tuaj yeem muaj kev kho mob hauv kev kho cov nqaij ntshiv cov kab mob xws li cov leeg nqaij dystrophy.

Myostatin (GDF8) tau qhia tshwj xeeb hauv tib neeg cov leeg pob txha raws li 12 kDa paub tab glycoprotein uas muaj 113 amino acid residues thiab tso rau hauv ntshav. Myostatin yog ib tug tswv cuab ntawm kev hloov pauv kev loj hlob ß superfamily ntawm secreted kev loj hlob thiab kev sib txawv yam uas yog qhov tseem ceeb rau kev tswj kom zoo ntawm cov pob txha pob txha. Cov kev tshawb fawb tau pom tias myostatin tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev txhim kho plawv thiab lub cev.

Noj ntau npaum:

Cov koob tshuaj ntawm Myostatin propeptide tau raug kuaj nas thiab nws tau pom tias muaj kev pom zoo ntawm cov leeg nqaij ntawm qhov koob tshuaj ntawm 20 mg / kg. Nws tuaj yeem siv txhua 5 hnub hauv 25 tsib hnub.

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