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Daim ntawv thov
Nws tau pom thawj zaug hauv cov leeg los ntawm Goldspink, thiab al. Hauv tib neeg cov leeg, ib qho 49- hauv paus ntxig hloov pauv cov kab ntawv nyeem hauv mechano loj hlob zoo (MGF) piv rau IGF-1.Thaum cov khoom siv ntau dhau tau qhia rau cov leeg (raws li kev cob qhia hnyav), IGF -1 gene tso tawm thiab yog sib txawv spliced ​​thaum lub cev teb. Thaum pib, nws yog spliced ​​los tsim feem ntau IGF-1Ec (hu ua MGF splice variant ntawm IGF-1). Qhov no thaum ntxov splicing stimulates satellite cell rau hauv kev ua kom. Uas nyob rau hauv lem tso cai rau kev ua kom cov ntxiv undamaged nuclei loj hlob tshiab nqaij fiber thiab ntaub so ntswg.

Cov tsos ntawm MGF kuj pib qhov kev tswj hwm ntawm cov protein synthesis tshiab. Tom qab qhov kev sib txuas thawj zaug ntawm IGF-1 rau hauv MGF, kev tsim khoom ces hloov mus rau kev tsim cov txheej txheem tso tawm ntawm IGF-1Ea los ntawm lub siab, uas kuj txhawb nqa cov protein synthesis thiab. Qhov kev qhia ntawm IGF-1 splice variants, dhau ntawm qhov kho thiab regrowth theem ntawm kev kho cov leeg yog xav tias yog thawj cov txheej txheem anabolic uas lub cev tsim cov leeg tshiab. MGF muaj nyob rau hauv kev txhaj tshuaj peptide, thiab nws tau ua pov thawj tias kev txhaj tshuaj yuav ua rau cov lus teb hauv cheeb tsam uas ua rau cov leeg nqaij loj hlob.

MGF (mechano growth factor) tau siv los ntawm bodybuilders thiab ncaws pob rau ob peb xyoos lawm. Tom qab kev tawm dag zog, IGF-1 raug tso tawm hauv cov leeg. Tshwj xeeb, nyob rau lub sijhawm no, tam sim ntawd tom qab siv cov leeg nqaij, IGF-I noob yog spliced ​​ntawm MGF uas pib hypertrophy thiab kho cov nqaij ntshiv hauv zos. Nws ua li ntawd ob qho tib si los ntawm kev ua kom cov leeg qia hlwb thiab cov hlwb satellite, tab sis kuj los ntawm ntau yam txheej txheem anabolic. Nws txawv ntawm "tsis tu ncua" IGF-1 feem ntau vim nws yog C-Terminal ib ntus. MGF tuaj yeem pib ua kom cov leeg nqaij satellite (stem) cell activation ntxiv rau nws cov IGF-Ireceptor domain uas ua rau nce cov protein synthesis turnover, thiab yog li ntawd tuaj yeem siv tau los txhim kho cov leeg nqaij lub sijhawm.

Kev piav qhia

MGF (Mechano Kev Loj Hlob) yog qhov sib txawv, kuj muaj xws li hluavtaws, dej-raws li variant nrog tsawg stability. MGF feem ntau yog muab los ntawm kev tawm dag zog los yog raug mob / puas cov leeg nqaij. Lub biomolecule mimic IGF noob qhia uas augments qia cell pejxeem nyob rau hauv cov leeg nqaij los txhawb hyperplasia. Ntxiv ntawm polyethylene glycol (PEG) nrog cov khoom sib xyaw tiv thaiv kev ua kom tsis muaj zog hauv cov ntshav, thiab ua kom cov ntshav nce ib nrab-lub neej.

MGF nthuav tawm cov teebmeem hauv zos hauv cov leeg pob txha thiab tsis tuaj yeem taug kev hauv lub cev yam tsis muaj kev hloov pauv. Qhov teeb meem nrog hluavtaws MGF yog tias nws tau nkag mus rau hauv intramuscularly thiab yog dej raws li nws nkag mus rau hauv cov ntshav. Thaum siv txoj kev no, MGF tsuas yog nyob ruaj khov hauv cov hlab ntshav rau ob peb feeb. Cov tshuaj lom neeg tsim tawm MGF yog tsim hauv zos thiab tsis nkag mus rau hauv cov hlab ntsha. Nws kuj yog luv luv ua yeeb yam li ntawd stability tsis yog ib qho teeb meem. Los ntawm PEGylating MGF nws yuav luag zoo li hauv zos tsim MGF thaum siv intramuscularly. Qhov no yog ua tiav los ntawm ib puag ncig ntawm peptide nrog cov qauv ntawm polyethylene glycol, uas tuaj yeem txuas rau cov protein molecule. Cov pab pawg polyethylene glycol tiv thaiv peptide tab sis tsis nyob ib puag ncig nws tag nrho. Cov chaw nquag ntawm peptide tseem muaj kev ywj pheej los ua lawv txoj haujlwm lom neeg. Nyob rau hauv cov ntaub ntawv no lub plhaub yog ib tug tsis zoo them daim thaiv tiv thaiv zoo nqi tebchaw uas yuav cuam tshuam rau cov protein.

Cov txiaj ntsig ntawm MGF

MGF Peptide Magnus Pharma nce cov qia hlwb hauv cov leeg
Kev nce loj hauv IGF1 ntau lawm los ntawm MGF Mechano Growth Factor Magnus Pharmaceuticals daim ntawv thov
Nce Protein Synthesis los ntawm MGF Mechano Growth Factor Magnus Pharmaceuticals
MGF peptide Magnus Pharmaceuticals tsub kom qhov kev loj hlob hormone tso tawm
Accelerates lub build-up ntawm cov leeg nqaij tshiab drastically
Txhawb kev tsim kho ntawm satellite cell
Ntxiv Regeneration los ntawm MGF Mechano Growth Factor Magnus Pharmaceuticals

MGF Dosage
Ib txoj cai raws cai yuav yog:
100-300mcg ntawm MGF muab faib ua 1-2 ob tog kev tswj hwm hauv 2-5 thaj chaw sib txawv ntawm cov leeg kwv yees li 5-7 hnub hauv ib lub lis piam - txhaj tshuaj intramuscular.
Piv txwv li, yog tias koj xav tswj hwm 200mcg ntawm MGF rau hauv siab thiab biceps cov leeg 2 zaug hauv ib hnub thiab 3 qhov sib txawv ntawm cov leeg nqaij ces koj yuav tsum tau faib cov koob tshuaj raws li hauv qab no:
200mcg / 2 zaug hauv ib hnub=100mcg rau kev tswj hwm
100mcg rau ib qho kev tswj hwm / 4 leeg (2 hauv siab thiab 2 leeg nqaij)=25mcg rau ib leeg
25mcg rau ib leeg / 3 qhov chaw sib txawv ntawm txhua tus leeg=8.3mcg rau ib qho kev txhaj tshuaj
Theoreticall, ntau qhov chaw siv los tswj MGF rau hauv cov leeg nqaij ntau qhov chaw rau cov leeg nqaij.

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