Oxytocin Basic Info
Khoom npe: Oxytocin
synonyms: plus cys-tyr-ile-gln-asn- plus cys- plus PRO-leu-gly-nh2; cys-tyr-ile-gln-asn-cys-PRO-leu-gly-nh2;
cyiqncplg-nh2; cyiqncplg-nh2 (disulfide choj: 1-6);h-cys-tyr-ile-gln-asn-cys-PRO-leu-gly-nh2;
h-cys-tyr-ile-gln-asn-cys-PRO-leu-gly-nh2, cys1,6, cyclic a-hypophamine
CAS: 50-56-6
MF: C43H66N12O12S2
PIB: 1007.19
EINECS: 200-048-4
Cov khoom lag luam: peptide; vasopressin thiab oxytocin receptor; cov tshuaj hormones
Cov khoom siv tshuaj lom neeg: dawb khoom
Purity (HPLC): 98.0 feem pua min.
Kev siv: lub tsev menyuam tseem ceeb-kev cog lus thiab lactation-stimulating hormone ntawm lub caj pas pituitary tom qab.
packing: Raws li xav tau
Kev piav qhia
Oxytocin yog ib qho tshuaj hormones uas ua haujlwm feem ntau yog neuromodulator hauv lub hlwb. Oxytocin paub zoo tshaj plaws rau nws lub luag haujlwm hauv kev sib deev, tshwj xeeb yog thaum thiab tom qab yug menyuam. Nws raug tso tawm ntau heev tom qab qhov mob ntawm lub ncauj tsev menyuam thiab lub tsev menyuam thaum lub sijhawm ua haujlwm, txhawb kev yug menyuam, thiab tom qab stimulation ntawm lub txiv mis, txhawb kev pub niam mis. Lo lus oxytocin tau muab los ntawm Greek lo lus, txhais tau tias yug sai, oxytocin peptide yog synthesized raws li ib tug inactive precursor protein los ntawm OXT noob.
Oxytocin yog peptide ntawm cuaj amino acids (ib qho nonapeptide). Nws lub npe hu ua cysteine-tyrosine-isoleucine-glutamine-asparagine-cysteine-proline-leucine-glycine-amine (cys, tyr, ile, gln, asn, cys, pro, leu, gly - NH2, los yog CYIQNCPLG-NH2). Cov cysteine residues tsim ib daim ntawv cog lus disulfide. Oxytocin muaj molecular loj ntawm 1007 daltons. Ib chav thoob ntiaj teb (IU) ntawm oxytocin yog qhov sib npaug ntawm li 2 micrograms ntawm peptide ntshiab. Kev ntseeg siab ntawm cov cuab yeej ntawm oxytocin tuaj yeem pab cov neeg uas raug kev txom nyem los ntawm kev ntxhov siab thiab kev xav tsis zoo, tab sis muaj peev xwm tsim kev tsim txom nrog kev ntseeg siab thiab kev siv tub rog.
Cov qauv ntawm oxytocin zoo ib yam li vasopressin (cys, tyr, phe, gln, asn, cys, pro, arg, gly - NH2), kuj yog ib qho nonapeptide nrog tus choj sulfur, uas nws sib txawv ntawm oxytocin los ntawm ob amino acids. . Ib lub rooj uas qhia cov kab ke ntawm cov tswv cuab ntawm vasopressin / oxytocin super tsev neeg thiab cov hom uas qhia lawv muaj nyob rau hauv kab lus vasopressin. Oxytocin thiab vasopressin raug cais thiab tsim los ntawm Vincent du Vigneaud hauv xyoo 1953, ua haujlwm rau nws tau txais Nobel nqi zog hauv Chemistry xyoo 1955. Oxytocin thiab vasopressin yog tib cov tshuaj hormones uas tau tso tawm los ntawm tib neeg lub caj pas pituitary tom qab ua haujlwm ntawm qhov deb. Txawm li cas los xij, oxytocin neurons ua lwm yam peptides, suav nrog corticotropin-tso cov tshuaj hormones thiab dynorphin, piv txwv li, uas ua hauv zos. Oxytocin muaj peripheral (hormonal) ua, thiab kuj muaj kev ua hauv lub hlwb. Nws cov yeeb yam yog kho los ntawm qhov tshwj xeeb, siab oxytocin receptors. Lub oxytocin receptor yog G-protein-coupled receptor uas yuav tsum tau Mg2 ntxiv thiab cov roj cholesterol.
Txhua yam kev xav tau, thov hu rau kuv
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