| Khoom npe | Pregabalin |
| Alias | 3-(aminomethyl)-5-methyl-hexanoic acid; Pregablin; (3S)-3-(aminomethyl)-5-methyl-hexanoic acid; (R-)-3-isobutyl GABA; 3-isobutyl GABA; CI 1008; CI-1008; 3-(aminomethyl) -5-methyl-(3S)-Hexanoic acid; 3-(aminomethyl) -5-methyl-(S)-Lyrica; PD 144723; PD-144723; Pregabalin [USAN]; TOS-BB-0910; Pregabalin nruab nrab; (3R) -3-(aminomethyl) -5-methylhexanoic acid; (S)-Pregabalin; (S)(plus )-3-Aminomethyl-5-methyl-hecanoic acid |
| CAS | 148553-50-8 |
| EINECS | 253-874-2 |
| Molecular Formula | C8H17NO2 |
| Molecular Luj | 159.23 |
| Assay | 99.8% ua |
| Qhov ntom | 0.997g/cm3 |
| Boiling Point | 274 degree ntawm 760 mmHg |
| Flash point | 119.5°C dej |
| Vapor Siab | 0.00153mmHg ntawm 25 degree |
| InChI | InChI{{0}}/C8H17NO2/c1-6(2)3-7(5-9)4-8(10)11/h{11}} H,{12}},9H2,1-2H3,(H,10,11)/t{19}}/m0/s1 |
| Qhov tshwm sim | Dawb los yog dawb crystalline hmoov |
| Kev siv | Cov tshuaj antiepileptic tshiab. Siv nyob rau hauv kev kho mob ntawm peripheral neuropathy, los yog ib feem qaug dab peg |
Nqe lus piav qhia:
Pregabalin tau piav qhia txog tshuaj raws li (S){{0}}(aminomethyl)-5-methylhexanoic acid. Cov mis mos molecular yog C8H17NO2 thiab qhov hnyav molecular yog 159.23. Pregabalin yog dawb mus rau dawb, crystalline khoom nrog pKa1 ntawm 4.2 thiab pKa2 ntawm 10.6. Nws yog dawb do soluble hauv dej thiab ob qho tib si yooj yim thiab acidic aqueous daws. Lub cav ntawm qhov sib faib coefficient (n-octanol / 0.05M phosphate buffer) ntawm pH 7.4 yog 1.35.
LYRICA (pregabalin) Capsules yog muab los ntawm qhov ncauj thiab muab tso rau hauv cov tshuaj ntsiav tawv tawv uas muaj 25, 50, 75, 100, 150, 200, 225, thiab 300 mg ntawm pregabalin, nrog rau lactose monohydrate, cornstarch inactive, thiab . Lub plhaub plhaub muaj gelatin thiab titanium dioxide. Tsis tas li ntawd, cov txiv kab ntxwv capsule plhaub muaj cov hlau oxide liab thiab cov kaus mom dawb muaj sodium lauryl sulfate thiab colloidal silicon dioxide. Colloidal silicon dioxide yog ib qho kev pab tsim khoom uas tej zaum yuav los yog tsis muaj nyob rau hauv cov tshuaj ntsiav plhaub. Cov cwj mem luam ntawv muaj cov shellac, dub hlau oxide, propylene glycol, thiab potassium hydroxide. LYRICA (pregabalin) qhov ncauj tshuaj, 20 mg / mL, yog muab los ntawm qhov ncauj thiab muab los ua cov tshuaj ntshiab, tsis muaj xim muaj nyob rau hauv 16 ooj kua dej dawb HDPE lub raj mis nrog. Polyethylene-lined kaw. Cov tshuaj hauv qhov ncauj muaj 20 mg / mL ntawm pregabalin, nrog rau methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, dag strawberry #11545 thiab purified dej raws li cov khoom xyaw tsis muaj zog.
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