COA
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Khoom npe |
Toremifene citrate |
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CAS Nr. |
89778-27-8 |
Ntim Ntim |
1 KG / nruas |
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Hnub tsim khoom |
2018.4.01 |
Txee lub neej |
2020.3.31 |
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Txheem txais yuav |
Txheem export |
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Cov khoom ntawm kev tsom xam |
Specification |
Cov txiaj ntsig |
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Kev piav qhia |
Dawb los yog zoo li dawb crystalline hmoov |
Dawb crystalline hmoov |
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Solubility |
Dawb soluble nyob rau hauv pyridine thiab acetic acid (100), sparingly soluble nyob rau hauv methanol, me ntsis soluble nyob rau hauv ethanol, heev me ntsis soluble nyob rau hauv dej, thiab xyaum insoluble nyob rau hauv diethyl ether |
Dawb soluble nyob rau hauv pyridine thiab acetic acid (100), sparingly soluble nyob rau hauv methanol, me ntsis soluble nyob rau hauv ethanol, heev me ntsis soluble nyob rau hauv dej, thiab xyaum insoluble nyob rau hauv diethyl ether |
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Melting point |
159 ~ 163 degree |
16 0.5 ~ 161.0 degree |
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Kev txheeb xyuas |
Yuav tsum ua raws |
Ua raws |
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E-isomer |
Tsawg dua lossis sib npaug rau 0.5 feem pua |
0 feem pua |
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Tag nrho cov txheeb ze tshuaj |
Tsawg dua lossis sib npaug rau 1.0 feem pua |
0.1 feem pua |
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Cov hlau hnyav |
Tsawg dua lossis sib npaug li 10ppm |
<10ppm |
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Poob rau ziab |
Tsawg dua lossis sib npaug rau 1.0 feem pua |
0.2 feem pua |
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Toluene |
Tsawg dua lossis sib npaug rau 0.089 feem pua |
0 |
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Ethanol |
Tsawg dua lossis sib npaug rau 0.5 feem pua |
0 feem pua |
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Acetone |
Tsawg dua lossis sib npaug rau 0.5 feem pua |
0.2 feem pua |
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Tetrahydrofuran |
Tsawg dua lossis sib npaug rau 0.072 feem pua |
0.0001 feem pua |
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Chlorobenzen |
Tsawg dua lossis sib npaug rau 0.036 feem pua |
0 |
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Benzene |
Tsawg dua lossis sib npaug rau 0.0002 feem pua |
0 |
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Residue ntawm ignition |
Tsawg dua lossis sib npaug rau 0.1 feem pua |
0.04 feem pua |
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Assay |
Ntau dua lossis sib npaug li 98.5 feem pua |
99.7% ua |
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Xaus |
Tsim nyog |
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Nqe lus piav qhia:
Toremifene citrate yog ib hom tshuaj uas muaj nyob rau hauv chav kawm ntawm cov tshuaj hu ua selective estrogen receptor modulators (SERMs). Nws feem ntau yog siv los kho qee yam mob qog noj ntshav mis, tshwj xeeb hauv cov poj niam postmenopausal. Toremifene muaj nyob rau hauv daim ntawv ntawm qhov ncauj ntsiav tshuaj.
Kev kho mob qog noj ntshav mis: Toremifene citrate yog tshuaj los kho cov tshuaj estrogen receptor-zoo mob qog noj ntshav mis hauv cov poj niam tom qab yug menyuam. Nws ua haujlwm los ntawm kev thaiv cov teebmeem ntawm estrogen hauv cov ntaub so ntswg ntawm lub mis, yog li inhibiting kev loj hlob ntawm cov qog nqaij hlav cancer.
Estrogen receptor antagonist / agonist: Toremifene citrate ua raws li ob qho tib si estrogen receptor antagonist thiab agonist. Nws sib tw nrog cov tshuaj estrogen rau kev khi rau cov tshuaj estrogen receptors, thaiv cov tshuaj estrogen proliferative cuam tshuam hauv cov ntaub so ntswg ntawm lub mis. Txawm li cas los xij, hauv lwm cov ntaub so ntswg, xws li cov pob txha thiab lub tsev menyuam, nws tuaj yeem muaj cov tshuaj estrogen.
Kev mob tshwm sim: Feem ntau cov kev mob tshwm sim ntawm toremifene citrate tuaj yeem muaj xws li kub kub, qhov chaw mos los yog qhuav, tawm hws, xeev siab, kiv taub hau, qaug zog, thiab kev hloov pauv hauv daim siab enzyme. Qee tus poj niam kuj yuav muaj qhov nce ib ntus ntawm cov qog loj ua ntej nws pib ntsws.
Cov pob txha noj qab haus huv: Toremifene citrate tau pom tias muaj txiaj ntsig zoo rau cov pob txha noj qab haus huv los ntawm kev txo cov pob txha thiab txo cov kev pheej hmoo ntawm pob txha hauv cov poj niam tom qab yug me nyuam. Qhov no yog qhov tshwj xeeb vim tias kev kho mob qog noj ntshav mis qee zaum tuaj yeem ua rau cov pob txha poob.
Kev ceev faj thiab contraindications: Toremifene citrate feem ntau tsis pom zoo siv rau cov poj niam premenopausal lossis cov poj niam cev xeeb tub. Nws yuav tsum tau siv nrog ceev faj hauv cov neeg mob uas muaj keeb kwm ntawm cov ntshav txhaws, vim nws tuaj yeem ua rau muaj kev pheej hmoo ntawm thromboembolic. Kev saib xyuas lub siab ua haujlwm tsis tu ncua kuj tseem ceeb thaum kho.
Kev sib cuam tshuam tshuaj: Toremifene citrate tuaj yeem cuam tshuam nrog lwm cov tshuaj, suav nrog qee cov tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kab mob, thiab tshuaj uas cuam tshuam rau lub siab enzymes. Nws yog ib qho tseem ceeb kom qhia rau koj tus kws kho mob txog txhua yam tshuaj, suav nrog cov tshuaj hauv khw muag khoom thiab cov tshuaj ntxiv, uas koj noj.
Cov txiaj ntsig
Kev kho mob qog noj ntshav mis: Toremifene citrate feem ntau yog siv los kho cov tshuaj estrogen receptor-zoo mob qog noj ntshav mis hauv cov poj niam postmenopausal. Los ntawm kev thaiv cov teebmeem ntawm cov tshuaj estrogen hauv cov ntaub so ntswg ntawm lub mis, nws pab inhibit qhov kev loj hlob thiab kev sib kis ntawm cov qog nqaij hlav cancer. Nws tuaj yeem siv los ua kev kho mob tom qab phais, hluav taws xob, lossis tshuaj khomob kom txo tau txoj kev pheej hmoo ntawm mob qog noj ntshav.
Cov pob txha noj qab haus huv: Toremifene citrate tau pom tias muaj txiaj ntsig zoo rau cov pob txha noj qab haus huv hauv cov poj niam tom qab yug menyuam. Nws pab txo cov pob txha poob thiab tuaj yeem txo qhov kev pheej hmoo ntawm pob txha, uas yog qhov tseem ceeb tshwj xeeb vim tias kev kho mob qog noj ntshav mis tuaj yeem ua rau cov pob txha poob.
Estrogen receptor modulation: Raws li kev xaiv tshuaj estrogen receptor modulator (SERM), toremifene citrate exerts nws cov teebmeem los ntawm kev xaiv khi rau cov tshuaj estrogen receptors hauv cov ntaub so ntswg sib txawv. Nyob rau hauv cov ntaub so ntswg ntawm lub mis, nws ua raws li ib tug antagonist, thaiv cov proliferative teebmeem ntawm estrogen. Hauv lwm cov ntaub so ntswg, xws li pob txha, nws tuaj yeem muaj cov tshuaj estrogen zoo li, pab tswj cov pob txha ceev.
Kev tiv thaiv kab mob plawv: Qee cov kev tshawb fawb qhia tias toremifene citrate tuaj yeem muab cov txiaj ntsig zoo rau cov hlab plawv hauv cov poj niam tom qab yug me nyuam nrog mob qog noj ntshav. Nws tau cuam tshuam nrog kev txhim kho hauv lipid profile, suav nrog txo tag nrho cov roj (cholesterol) thiab qis lipoprotein (LDL) cov roj cholesterol. Cov teebmeem no yuav ua rau muaj kev pheej hmoo tsawg ntawm cov xwm txheej hauv plawv.
Lwm txoj rau tamoxifen: Toremifene citrate yog suav tias yog lwm txoj hauv kev tamoxifen, lwm SERM feem ntau siv hauv kev kho mob qog noj ntshav. Rau cov poj niam uas tsis tuaj yeem zam tamoxifen lossis tsis teb zoo rau nws, toremifene citrate tuaj yeem yog lwm txoj hauv kev uas muaj cov txiaj ntsig zoo sib xws.
Txhua yam kev xav tau, thov hu rau kuv
Email: amyraws195@gmail.com
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