Exemestane (Aromasin) CAS: 107868-30-4

Kev piav qhia

Exemestane, muag raws li lub npe Aromasin ntawm lwm tus, yog cov tshuaj siv los kho mob qog noj ntshav. Nws yog ib tug tswv cuab ntawm chav kawm ntawm antiestrogens hu ua aromatase inhibitors. Qee cov qog nqaij hlav hauv lub mis xav tau cov tshuaj estrogen kom loj hlob. Cov qog nqaij hlav no muaj cov tshuaj estrogen receptors (ERs), thiab hu ua ER-zoo. Lawv kuj tseem hu ua estrogen-responsive, hormonally-responsive, lossis hormone-receptor-positive. Aromatase yog ib qho enzyme uas tsim cov tshuaj estrogen. Aromatase inhibitors thaiv cov synthesis ntawm estrogen. Qhov no txo ​​qis cov tshuaj estrogen, thiab slows txoj kev loj hlob ntawm cov qog nqaij hlav.

Muaj ntau cov qog nqaij hlav hauv lub mis yog txhawb kom loj hlob los ntawm poj niam txiv neej cov tshuaj hormones estrogen thiab progesterone. Cov qog nqaij hlav hauv lub mis no yog hu ua cov tshuaj hormone rhiab lossis hormone receptor zoo. Thaiv cov teebmeem ntawm cov tshuaj hormones no tuaj yeem kho mob cancer mis.

Hauv cov poj niam uas tau muaj lawv cov menopause, estrogen feem ntau yog tsim los ntawm kev hloov androgens (cov tshuaj hormones poj niam txiv neej ua los ntawm cov qog adrenal) rau hauv estrogens. Cov txheej txheem no yog hu ua aromatisation thiab tshwm sim feem ntau hauv cov nqaij rog, nqaij thiab tawv nqaij. Nws xav tau ib qho enzyme hu ua aromatase.

Exemestane thaiv cov txheej txheem ntawm aromatisation. Yog li nws txo qis cov tshuaj estrogen hauv lub cev. Hauv kev mob qog noj ntshav thaum ntxov, kev noj tshuaj exemestane tuaj yeem pab kom tsis txhob mob qog noj ntshav ntawm lub mis rov qab los. Hauv kev mob qog noj ntshav siab, cov qog nqaij hlav cancer yuav loj hlob qeeb dua lossis tsis loj hlob tag nrho.

Cov ntaub ntawv kho mob

Kev siv tshuaj Aomasin

Qhov no aromatase inhibitor yog qhia rau

kev kho mob cancer ntawm lub mis mob cancer ntawm lub mis hauv cov poj niam uas tsis muaj lawv lub cev xeeb tub, ib txwm yog vim lawv lub hnub nyoog (tom qab menopause) los yog vim lawv tau muaj lawv lub zes qe menyuam phais.

Kev pheej hmoo txo ​​rau kev mob qog noj ntshav mis hauv cov poj niam postmenopausal.

Mechanism ntawm kev ua

Hauv cov poj niam premenopausal, zes qe menyuam yog lub hauv paus ntawm cov tshuaj estrogen tab sis hloov cov tshuaj estrogen los ntawm aromatase enzyme nyob rau hauv cov ntaub so ntswg peripheral thiab qee qhov ntawm lub hlwb yog lub hauv paus ntawm cov tshuaj estrogen hauv cov poj niam tom qab menopausal. Exemestane yog ua raws li qhov nruab nrab thiab khi rau qhov chaw nquag ntawm cov enzyme. Qhov kev khi no ua rau inactivation hu ua "suicide inhibition". Cov tshuaj no zoo ib yam li lub hom phiaj enzyme; si nws mus tas li khi rau cov enzyme, tiv thaiv lawv los ntawm hloov androgen rau hauv estrogen.

Cov txiaj ntsig ntawm Exemestane yog dab tsi?

Thaum tus neeg siv siv cov tshuaj pom zoo ntawm Exemestane, nws yuav muab ntau yam txiaj ntsig xws li:

● Ua kom ceev qhov tso tawm ntawm cov tshuaj insulin zoo li kev loj hlob

● Cov dej num androgenic qis dua

● Ceev ceev cov txheej txheem ntawm testosterone synthesis

● Nce concentration ntawm IGF yam

● Tiv thaiv cov leeg nqaij los ntawm kev puas tsuaj

●Nws sib npaug anabolism thiab catabolism ntawm cov neeg siv

●Nws tiv thaiv cov neeg siv tshuaj steroids los ntawm cov kev mob tshwm sim estrogenic (xws li gynecomastia, dej thiab kua dej tuav thiab tsam plab)

● Txo cov poj niam cov tshuaj hormones

● Txhim kho cov leeg mob

● Txhawb kev loj hlob ntawm anabolic keeb kwm yav dhau

●Nws tiv thaiv cov neeg siv los ntawm kev kub siab

● Txo qhov tsis zoo ntawm cov tshuaj estrogen ntawm lub caj pas pituitary

●Txhua cov txiaj ntsig cov neeg siv tuaj yeem tau txais thaum lawv siv cov khoom zoo. Ib txwm yuav Exemestane los ntawm cov peev txheej saum toj kawg nkaus. Hauv internet ua rau nws yooj yim mus nrhiav Exemestane rau muag.

Dab tsi yog qhov txawv ntawm Arimidex thiab Aromasin?

Arimidex yog lub npe nrov rau anastrozole. Nws tau pom zoo los ntawm FDA hauv xyoo 1995, thiab nws yog siv los kho cov tshuaj hormone receptor-positive receptor thaum ntxov mob qog noj ntshav hauv cov poj niam postmenopausal. Arimidex muaj nyob rau hauv 1 mg ntsiav tshuaj noj ib hnub ib zaug nrog lossis tsis muaj zaub mov. Kev nqus ntawm Arimidex hauv lub cev tsis cuam tshuam los ntawm cov khoom noj. Arimidex yog tsim los ntawm ANI Pharmaceuticals.

Aromasin yog lub npe nrov rau exemestane. Nws tau pom zoo los ntawm FDA hauv 1999, thiab nws yog siv los kho cov tshuaj hormone receptor-zoo receptor thaum ntxov mob qog noj ntshav hauv cov poj niam tom qab yug menyuam uas twb tau siv tamoxifen rau ob mus rau peb xyoos. Aromasin muaj nyob rau hauv ib ntsiav tshuaj 25 mg ib hnub ib zaug tom qab noj mov. Cov zaub mov tau pom tias yuav pab txhawb kev nqus ntawm Aromasin los ntawm lub cev. Aromasin yog tsim los ntawm Pfizer.

Puas yog Arimidex lossis Aromasin zoo dua?

Arimidex thiab Aromasin yog cov kev kho mob cancer mis zoo. Kev kho mob cancer mis zoo tshaj plaws yuav nyob ntawm ntau yam xws li tus neeg teb rau kev kho mob, txhua yam kev mob tshwm sim, thiab tus nqi kho mob. Tus kws kho mob yuav tsum tau sab laj los txiav txim qhov kev xaiv zoo tshaj plaws.

Anastrozole thiab exemestane, cov khoom xyaw nquag hauv Arimidex thiab Aromasin, feem, tau muab piv rau hauv kev sim tshuaj taub hau. Ib txoj kev tshawb fawb luam tawm hauv Lancet Oncology piv rau anastrozole, exemestane, thiab letrozole. Txoj kev tshawb nrhiav pom tias cov tshuaj aromatase inhibitors zoo sib xws rau kev kho cov tshuaj hormone receptor-zoo mob qog noj ntshav mis. Txoj kev tshawb no tseem pom tau tias tsib xyoos ntawm aromatase inhibitor kho tsis zoo tshaj li ob xyoos ntawm kev kho tamoxifen tom qab siv cov aromatase inhibitor rau peb xyoos.

Lwm txoj kev tshawb fawb luam tawm nyob rau hauv Phau ntawv Journal of Clinical Oncology pom tias ob qho tib si aromatase inhibitors zoo ib yam li kev kho mob rau cov mob qog noj ntshav tom qab yug menyuam. Qhov kev txiav txim siab tseem ceeb ntawm aromatase inhibitors tuaj yeem yog kev zam ntawm cov tshuaj hais txog cov kev mob tshwm sim. Tib txoj kev tshawb nrhiav pom tias exemestane tuaj yeem yog ib qho kev xaiv rau kev kho mob pem hauv ntej rau kev kho mob postmenopausal hormone receptor-zoo mob qog noj ntshav mis yam tsis tas yuav tsum tau ob mus rau peb xyoos ntawm kev kho tamoxifen ua ntej.

Peb Qhov Zoo

1.Quality: txhua yam khoom raug soj ntsuam nruj me ntsis los ntawm peb cov neeg ua haujlwm tshaj lij thiab tau txais daim ntawv pov thawj ISO.
2.Price: qis dua peb cov phooj ywg vim peb yog lub Hoobkas. Ib qho luv nqi yuav muab thaum koj txiav txim loj.
3.Delivery: Peb muaj cov Tshuag txaus kom peb tuaj yeem ua tus xa tuaj hauv 24 teev tom qab them nyiaj.
4.Perfect Reshipping txoj cai tau ua los tiv thaiv cov neeg siv khoom max txiaj ntsig thiab txo cov peev txheej poob.
5.Kev pab cuam tom qab muag zoo: ib txwm ua raws li cov xwm txheej ntawm koj cov pob khoom kom txog rau thaum xa thiab sim peb lub siab tshaj plaws los daws cov neeg siv khoom teeb meem entounered
6.main khoom: Raw steroids, tib neeg txoj kev loj hlob hormone, Semi-tiav roj, bodybuilding peptides, SARMs raws li, Anabolic steroids