Anti Estrogen Steroids Tamoxifen Citrate Powder Nolvadex CAS 54965-24-1 Tawm tsam Mob Cancer

Khoom npe: Tamoxifen citrate

Khoom Paub meej:

Khoom npe: Tamoxifen Citrate
Alias: Tamoxifen, Nolvadex, Tamofen
CAS Registry Number: 54965-24-1
EINECS: 259-415-2
Kev Ntsuas: 99 feem pua
Cov mis mos molecular: C26H29NO.C6H8O7
Molecular Luj: 563.64
MP: 140-144 oC
Cov tsos mob: dawb crystalline hmoov
Qib: Pharmaceutical Qib
Ntawv pov thawj: USP / ISO9000
Kev siv: cov khoom siv los tiv thaiv estrogen fertility inducer, cov khoom hauv uterine dysfunctional los ntshav, polycystic zes qe menyuam, kev coj khaub ncaws thiab tshuaj amenorrhea thiab lwm yam kab mob gynecologic; Nws yog siv los ua thawj kab tiv thaiv kab mob cancer mis.

Nqe lus piav qhia:

Nolvadex thiab Clomid yog ob qhov nrov tshaj plaws Selective Estrogen Receptor Modulators (SERMs) nyob hauv lub ntiaj teb thiab ib feem ntawm cov phiaj xwm ntxiv rau ntau qhov kev ua tau zoo txhawb cov neeg ncaws pob. Ntau tus neeg ncaws pob yuav Nolvadex rau PCT lub hom phiaj dua li lwm lub hom phiaj; Qhov tseeb, ntau qhov kev ua tau zoo txhim kho yuav Nolvadex rau lawv cov PCT siv dua li lwm cov tshuaj muaj.

Qhov tseeb, ntau qhov kev ua tau zoo dua yuav Nolvadex rau lawv cov PCT siv dua li lwm cov tshuaj muaj. Raws li koj nkag siab lub hom phiaj ntawm lub sijhawm PCT yog los txhawb kev tsim cov tshuaj testosterone ntuj tom qab lub voj voog ntawm anabolic steroids tau raug txiav lawm; Qhov no yog qhov tsim nyog raws li anabolic steroids suppress natural testosterone ntau lawm. Ntxiv mus, dhau ntawm testosterone stimulation no yog lub sij hawm thaum peb pib normalizing peb lub cev tab sis nyob rau hauv cov ntaub ntawv ntawm Tamoxifen Citrate nws yog testosterone ntau lawm peb muaj kev txhawj xeeb nrog ntawm no.

Gynecomastia (txiv neej lub mis loj) yog ib qho kev txhawj xeeb tshaj plaws uas tuaj yeem tshwm sim vim siv anabolic androgenic steroid, hmoov zoo koj tuaj yeem yuav Nolvadex thiab tawm tsam cov nyhuv no; Tsis yog, Tamoxifen Citrate yuav tsis txo cov tshuaj estrogen hauv koj lub cev tab sis nws yuav tiv thaiv ib feem ntawm nws los ntawm kev khi thiab qhov no muab kev tiv thaiv.

Thaum gyno prone anabolic steroid cov neeg siv khiav aromatising tebchaw, xws li testosterone los yog dianabol, lawv hloov mus rau estrogen. Qhov no tuaj yeem ua rau cov txiv mis puffy, tsam plab, ntshav siab, erectile kawg thiab lwm yam tshuaj estrogen. Nolvadex tuaj yeem tiv thaiv qee qhov kev mob tshwm sim ntawm cov tshuaj estrogen los ntawm qhov tshwm sim, thiab nws tuaj yeem cuam tshuam kev loj hlob ntawm gynecomastia. Txawm li cas los xij, hauv kuv lub tswv yim, siv AI muaj txiaj ntsig zoo dua rau kev tswj hwm tshuaj estrogen.

Hauv kev xyaum, tamoxifen yog qhov zoo tshaj plaws siv los pab txhawb LH thiab tag nrho cov testosterone. Qhov no yuav pab koj rov qab los ntawm lub voj voog, uas ua rau nws yog qhov kev xaiv nrov rau kev kho tom qab lub voj voog. Ib qho clomiphene, tamoxifen ua ke yog ib qho kev xaiv zoo tshaj plaws rov qab rau feem ntau ntawm PCT regiments.

Daim ntawv thov:

Tamoxifen citrate Tsis ua raws li LH hauv lub cev, tab sis nws txhawb lub hypophysis kom tso ntau gonadotropins. Gonadotropins yog cov tshuaj hormones protein uas tso tawm los ntawm gonadotrope hlwb ntawm lub caj pas pituitary thiab txhawb nqa sai thiab ntau dua tso tawm ntawm follicle stimulating hormone thiab luteinizing hormone. Thaum qhov no tshwm sim, qhov nce hauv LH yuav nce siab tag nrho cov qib testosterone uas tso cai rau kev kho kom zoo tom qab lub voj voog. Yog li ntawd, qhov no yuav pab koj txo qis kev poob ntawm cov leeg nqaij kom txog thaum koj lub cev tuaj yeem rov qab los.

Interestingly, tamoxifen ua haujlwm ib yam li clomiphene, los ntawm kev txwv cov tshuaj estrogen los ntawm kev nkag mus rau hauv pituitary, uas ua rau nws tsim LH. Nyob rau hauv lem, nws mam li qhia rau leydig hlwb los tsim testosterone. Ntau tus neeg siv ntawm nolvadex tau khiav cov ntshav ua haujlwm uas qhia LH qib nce los ntawm 0 mus rau ntau dua 10iu, uas yog siab dua qhov kev hais txog ib txwm muaj rau cov txiv neej laus. Raws li qhov tshwm sim ntawm qhov no, koj qib testosterone nce.

Rau kev kho mob siab, mob qog noj ntshav ntawm lub mis thiab mob qog noj ntshav thiab lwm yam mob. Siv los ua cov khoom siv antineoplastic.
Kev Ua Txhaum Cai: Estrogen receptor antagonist / ib nrab agonist. Xaiv thiab muaj zog inhibitor ntawm mammalian sterol isomerase. Neuroprotective hauv poj niam nas hauv vivo. Kuj tseem muaj kev sib raug zoo agonist ntawm daim nyias nyias estrogen receptor GPR30.

Specification:

Tamoxifen citrate Dosage, Indications thiab siv:

Tamoxifen Citrate Tablets (TCT) yog ib qho kev sib tw estrogen antagonist thiab cov tshuaj nonsteroidal anti-estrogen. Nws yog feem ntau siv kho mob los kho txhua hom mob qog noj ntshav mis, thiab nws yog qhov tshwj xeeb tshaj yog rau cov poj niam postmenopausal poj niam mob qog noj ntshav uas yog cov tshuaj estrogen receptor thiab progesterone receptor zoo thiab muaj cov qib qis ntawm prostrate tshwj xeeb antigens. Tamoxifen citrate muaj kev tiv thaiv qog nqaij hlav thiab tshuaj tiv thaiv kab mob, thiab nws tuaj yeem siv rau kev tiv thaiv lub plawv thiab kho mob qog noj ntshav siab thiab mob qog noj ntshav ntawm zes qe menyuam.

Kev noj ntau npaum li cas los ntawm 10mg - 60mg txhua hnub.Nws yog ib qho tseem ceeb uas yuav tau pib PCT ib zaug koj ua tiav lub voj voog steroid kom tsis txhob muaj qhov poob loj ntawm qhov tau txais. Cov lus nug txog yuav pib PCT sai npaum li cas yog nyob ntawm hom steroids koj siv. Yog tias koj lub voj voog muaj nyob ntawm qhov ncauj, uas muaj qhov cuam tshuam luv tshaj plaws ntawm lub cev, nws raug nquahu kom pib tam sim ntawd. Qee tus hais tias PCT tuaj yeem pib ntxov li hnub kawg ntawm lub voj voog steroid. Yog tias cov tshuaj esters luv luv lossis cov tshuaj txhaj dej raws li dej, PCT raug pom zoo 4-7 hnub tom qab txhaj tshuaj kawg. Nyob rau hauv cov ntaub ntawv ntawm cov esters ntev, nws yuav tsum nyob ib ncig ntawm 10-14 hnub tom qab txhaj tshuaj kawg.

Tamoxifen citrate neeg siv:

Tamoxifen citrate tuaj yeem cuam tshuam cov qog loj hlob raws li nws khi ua ntej nrog cov cell receptors txawm tias ua ntej cov tshuaj estrogen mus txog qhov chaw receptor. Thiab peb hais tias tamoxifen citrate yog cov tshuaj uas ntseeg siab tshaj plaws thiab muaj kev nyab xeeb vim nws tsis txwv kev tsim cov tshuaj estrogen.

Txawm hais tias cov tshuaj twb tau siv ntau xyoo, nws tau raug tshuaj tas li los ntawm kws kho mob vim tias nws yog qhov kev xaiv nyab xeeb tshaj plaws, tab sis qhov kev kho mob zoo tshaj plaws rau cov tshuaj hormones zoo rau cov qog nqaij hlav mis. Thaum peb hais tias cov tshuaj hormone receptive zoo nws yeej txhais tau hais tias cov qog tau noj los ntawm estrogen.

Pharmacodynamics:

Tamoxifen citrate ntsiav tshuaj tau noj hauv qhov ncauj thiab nqus tau maj mam, siv li 3-6 teev kom ncav cuag cov ntshav siab. Tom qab nqus tau, tamoxifen citrate ntsiav tshuaj 'lub siab metabolite yog N- desmethyl tamoxifen, uas muaj cov haujlwm zoo sib xws rau tamoxifen citrate. Cov tshuaj tshem tawm ib nrab-lub neej yog 5-7 hnub thiab nws cov metabolite N-desmethyl tamoxifen lub neej ib nrab yog 7-14 hnub. Kev sim tsiaj pom tau tias tamoxifen citrate thiab N-desmethyl tamoxifen tau dav dav hauv cov hnyuv thiab daim siab. Rau ib koob tshuaj 20mg ntawm tamoxifen citrate, nws cov ntshav siab tshaj plaws yog 40ng / ml (ntau: 67-183ng / ml) thiab 336ng / ml (ntau: 148-654 ng / ml). Tamoxifan citrate nce mus txog cov ntshav ruaj khov tom qab siv tas li rau 3-4 lub lis piam, thaum N-desmethyl tamoxifen xav tau 3-8 lub lis piam. Tamoxifen citrate thiab nws cov metabolites feem ntau yog tawm hauv cov quav, thiab me me ntawm cov metabolites raug tso tawm hauv cov zis.