Hmoov Dimethocaine

Kev piav qhia

Dimethocaine, feem ntau hu ua DMC los yog lidocaine, yog cov tshuaj muaj zog stimulatory. Qhov kev cuam tshuam no piv nrog cov yeeb yaj kiab, txawm li cas los xij, dimethicone zoo li tsis muaj zog. Ib yam li cov yeeb yaj kiab, dimethicone methane yog qhov muaj yees vim nws qhov kev ua haujlwm ntawm qhov khoom plig hauv lub hlwb.

Txawm li cas los xij, dimethicone yog kev hloov cov yeeb yaj kiab raug cai hauv qee lub tebchaws thiab tseem muaj npe los ntawm European Monitoring Center for Drugs and Drug Addiction (EMCDDA) nyob rau hauv qeb "synthetic cocaine derivatives". Cov qauv ntawm dimethicone, ua ib tug 4-aminobenzoic acid ester, zoo li procaine. Nws pom tau tias yog hmoov dawb ntawm chav tsev kub.

Thaum cov khoom lag luam muag hauv online hauv UK thaum Lub Rau Hli 2010, sau tias yog dimethicone raug tshuaj xyuas, nws tau qhia tias yog kev sib xyaw ntawm caffeine thiab lidocaine, thiab qhov tsis muaj cov tshuaj dopaminergic stimulant hauv cov khoom sib xyaw no tuaj yeem piav qhia txog qhov txwv kev ua si uas tau thov los ntawm ntau tus. cov neeg siv khoom.

Lwm cov qauv kuaj tau tseem muaj pov thawj muaj xws li dimethicone tiag tiag, thiab ib lub npe "da dej ntsev" cov khoom uas muaj feem ntau dimethicone ua cov tshuaj tiv thaiv, tau pom tias muaj kev pheej hmoo tshwj xeeb rau kev siv tsis raug los ntawm cov neeg siv tshuaj yeeb hauv Ireland.

Keeb kwm thiab txheej txheem cej luam

Cov tshuaj loog hauv zos hais txog cov tshuaj uas ua rau ib feem ntawm tib neeg lub cev tsis hnov ​​​​tsw tsis hnov ​​​​qab, txhawm rau pab txhawb kev phais. Lawv feem ntau siv hauv kev kho hniav, kho qhov muag, gynecology thiab qee qhov kev phais me me kom txo tau qhov mob ib ntus. Tom qab cov tshuaj loog hauv zos khi rau qee qhov tshwj xeeb ntawm sodium ion channel ntawm cov paj hlwb, cov sodium ions dhau los ntawm sodium ion channels raug txo, yog li hloov cov paj hlwb muaj peev xwm, ua rau muaj kev cuam tshuam ntawm cov hlab ntsha impulses, thiab thaum kawg. ua tiav cov nyhuv tshuaj loog. Dimethocaine yog nws cov khoom sawv cev.

Yam ntxwv

Dimethocaine, tseem hu ua aminobenzoic acid-3-(diethylamino)-2, 2-dimethylpropyl ester, yog lub teeb daj nrog ib qho alkalinity thiab tsw ntxhiab tshwj xeeb. Nws yog soluble hauv ntau cov kuab tshuaj organic, xws li ethanol, ether thiab benzene, thiab yog siv dav hauv tshuaj loog hauv zos, organic synthesis thiab tshuaj tshawb fawb thiab kev loj hlob. Piv nrog rau lwm cov tshuaj loog hauv zos, dimethocaine tsis tsuas yog muaj zog, ceev thiab ntev-ntev tshuaj loog nyhuv, tab sis kuj muaj toxicity tsawg. Tsis tas li ntawd, nws kuj tau siv dav hauv kev tshawb fawb hauv kev tshawb fawb thiab kev tsim kho thiab kev tsim tshuaj chemical.
Dimethocaine feem ntau yog siv los ua tshuaj nruab nrab. Nws tseem tuaj yeem siv los ua cov khoom siv hluavtaws thiab cov khoom siv dyes. Dimethocaine yog ib qho tshuaj loog hauv zos nrog cov khoom zoo sib xws rau cov yeeb yaj kiab. Cov tshuaj loog hauv zos yog ib chav kawm ntawm cov tshuaj uas tuaj yeem thaiv cov paj hlwb thiab feem ntau yog siv rau qhov chaw tshuaj loog ntawm lub qhov ntswg, qhov ntswg mucosa, pharyngeal trachea, urethral mucosa, thiab lwm yam. Tsis tas li ntawd, hauv cov khoom siv hluavtaws hluavtaws, dimethocaine tuaj yeem siv los ua cov organic ua haujlwm. molecules nrog lom lom [1].
Ntawm 0 degree, methacryloyl chloride tau ntxiv dropwise mus rau ib qho kev sib xyaw ntawm dimethocaine, NEt3 thiab DMAP kom tau txais lub hom phiaj cov khoom molecule tom qab cov tshuaj tiv thaiv.

Kev siv Dimethocaine

Dimethocaine tuaj yeem siv los ua tshuaj loog hauv zos, uas muaj cov txiaj ntsig zoo sib xws rau cov yeeb yaj kiab. Cov tshuaj loog hauv zos (lub npe hu ua tshuaj loog hauv zos) xa mus rau cov chav kawm ntawm cov tshuaj uas tuaj yeem thaiv cov hlab ntsha thaum siv rau cov paj hlwb hauv zos ntawm qhov tsim nyog. Lawv tuaj yeem ua rau txhua qhov ntawm lub paj hlwb thiab ntau hom paj hlwb. Hom kev ua ntawm dimethocaine yog qhov tshuaj loog, uas ncaj qha ua rau ntawm qhov chaw mucosal. Nws yog feem ntau siv rau conjunctiva, qhov ntswg mucosa, pharyngeal trachea, thiab urethral mucosa. Qee tus neeg kuj siv rau ntawm daim tawv nqaij, tshwj xeeb tshaj yog rau cov menyuam yaus ntawm daim tawv nqaij. Tom qab ib nrab teev ntawm daim ntawv thov, kev txhaj tshuaj tsis mob lossis puncture tuaj yeem ua hauv zos. Hauv cov organic synthetic chemistry, dimethocaine tuaj yeem siv los ua ke cov organic ua haujlwm molecules nrog kev ua haujlwm lom neeg. Nrog kev pab los ntawm nucleophilicity ntawm cov amino pawg hauv nws cov qauv, nws tuaj yeem hloov mus rau hauv cov khoom sib txuam amide derivatives nyob rau hauv qhov kev txiav txim ntawm acyl chlorides, thiab tuaj yeem hloov mus rau hauv theem nrab lossis tertiary amine compounds los ntawm alkylation cov tshuaj tiv thaiv nrog alkyl halides. [1]

Methacryloyl chloride (6.0 mmol) tau ntxiv dropwise rau qhov sib xyaw ntawm dimethocaine (5.0 mmol), NEt3 (1.4 mL, 10 mmol) thiab DMAP (3{{ 25}} mg, 250 μmol) hauv CHCl3 (1{29}} mL) ntawm 0 degree . Cov tshuaj tiv thaiv sib tov tau muab rhaub rau hauv chav tsev kub thiab nplawm kom txog thaum cov khoom pib siv tag nrho (1-3 teev). H2O (kwv yees li 20 mL) tau ntxiv rau cov tshuaj tiv thaiv sib xyaw thiab cov tshuaj tiv thaiv sib xyaw tau muab rho tawm nrog CHCl3 (li 20 mL x 2). Cov feem ntawm cov organic sib xyaw ua ke thiab qhuav dhau Na2SO4. Cov feem ntawm cov organic yog concentrated nyob rau hauv vacuo thiab ib tug tov ntawm cov tshwm sim residue nyob rau hauv qhuav THF (10 mmol) yog ntxiv dropwise rau ib ncua kev kawm ntawv ntawm NaH (60% dispersion nyob rau hauv paraffin, 240 mg, 6.0 mmol) nyob rau hauv qhuav THF (10 mL) ntawm 0 degree. Cov txiaj ntsig sib xyaw tau nplawm hauv chav sov li 5 feeb, thiab tom qab ntawd halogenated muaj ntxhiab hydrocarbon (0.7 mL, 5.5 mmol) tau ntxiv dropwise rau cov tshuaj ntawm 0 degree, thiab cov tshuaj tau nplawm ntawm chav tsev kub thaum hmo ntuj. Ib qho tshuaj aqueous ntawm NaHCO3 (20 mL) tau ntxiv rau cov tshuaj tiv thaiv sib xyaw. Cov sib tov tau muab rho tawm nrog EtOAc (30 mL × 3), cov organic sib xyaw ua ke tau qhuav dhau Na2SO4, thiab cov organic sib xyaw ua ke tau concentrated hauv vacuo. Cov residue tau huv si los ntawm silica gel kem chromatography siv ib tug gradient ntawm n-hexane/EtOAc=12-100% kom tau cov hom phiaj khoom molecule. [2]

Dab tsi yog dimethocaine tshuaj rau?

Dimethocaine(tseem hu ualarocaine) yog atshuaj loog hauv zosnrog stimulant zog, zoo ib yam li cocaine. Txawm li cas los xij,Dimethocaine feem ntau tsis yog tshuaj rau kev siv kho mobnyob rau hauv ntau lub teb chaws, tshwj xeeb tshaj yog nyob rau hauv lub xyoo tsis ntev los no, vim hais tias ntawm nws lub peev xwm rau kev tsim txom thiab tsis muaj ib tug tseem ceeb kev kho mob zoo dua lwm txoj kev nyab xeeb.

Yav dhau los, nws tau siv rautshuaj loog hauv zosHauv kev phais me me lossis cov txheej txheem kho hniav, raws li nws ib ntus loog ntawm thaj chaw uas nws tau thov, zoo ib yam li lwm yam tshuaj loog xws li lidocaine lossis procaine.

Cov ntsiab lus tseem ceeb:

Local tshuaj loog: Feem ntau yog rau cov ntaub so ntswg thaum kho mob lossis kho hniav.

Cov teebmeem tshwm sim: Nws muaj cov tshuaj stimulant me me, zoo ib yam li yeeb dawb, uas ua rau nws muaj peev xwm tsim txom.

Vim nws cov khoom stimulant thiab cov kev pheej hmoo cuam tshuam,Dimethocaine feem ntau cuam tshuam nrog kev siv ua sithiab suav hais tias yog cov tshuaj tswj tau hauv ntau thaj tsam. Muaj kev nyab xeeb thiab siv ntau dua cov tshuaj loog hauv zos xws li lidocaine lossis procaine tau hloov pauv ntau hauv cov chaw kho mob.

Peb Qhov Zoo

1.Quality: txhua yam khoom raug soj ntsuam nruj me ntsis los ntawm peb cov neeg ua haujlwm tshaj lij thiab tau txais daim ntawv pov thawj ISO.
2.Price: qis dua peb cov phooj ywg vim peb yog lub Hoobkas. Ib qho luv nqi yuav muab thaum koj txiav txim loj.
3.Delivery: Peb muaj cov Tshuag txaus yog li peb tuaj yeem ua tus xa hauv 24 teev tom qab them nyiaj.
4.Perfect Reshipping txoj cai tau ua los tiv thaiv cov neeg siv khoom max txiaj ntsig thiab txo cov peev txheej poob.
5.Qhov kev pab cuam tom qab muag zoo: ib txwm ua raws li cov xwm txheej ntawm koj cov pob khoom kom txog thaum xa thiab sim peb lub siab tshaj plaws los daws cov neeg siv khoom teeb meem entounered
6.main khoom: Raw steroids, tib neeg txoj kev loj hlob hormone, Semi-tiav roj, bodybuilding peptides, SARMs raws li, Anabolic steroids