Hmoov Dutasteride

Kev piav qhia

"Dutasteride yog ib qho tshuaj uas thaiv cov enzyme hu ua 5-alpha reductase (5-AR)," piav qhia Dr. Simon Pimstone, tus tsim, thiab tus thawj coj, ntawm XYON Health Inc. "Cov enzyme no yog lub luag haujlwm rau kev tsim cov dihydrotestosterone (lossis DHT), uas yog androgen hormone uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm prostate thiab txiv neej qauv plaub hau poob.

Dutasteride feem ntau siv nyob rau hauv cov xwm txheej uas cov plaub hau poob yog qhov dav lossis tsis teb rau lwm txoj kev kho mob hu ua finasteride.

Ob qho kev kho mob no thaiv 5-AR, txawm li cas los xij, Pimstone taw qhia tias dutasteride inhibits ob hom enzyme hu ua isoforms I thiab II, thaum finasteride tsuas ua rau isoform II.

Finasteride tseem tsuas thaiv txog 70% ntawm kev hloov pauv ntawm testosterone rau hauv DHT. Dutasteride tuaj yeem thaiv ntau dua 90% Trusted Source.

Noj dutasteride qhov ncauj ua haujlwm los ntawm kev txwv tsis pub hloov pauv ntawm testosterone rau DHT hauv lub cev kom DHT tsis muaj sijhawm mus txog cov hauv paus plaub hau.

Thaum siv tshuaj pleev ib ce, nws ua haujlwm los ntawm kev tso tseg DHT hloov pauv hauv cov hauv paus plaub hau.

Pharmacological kev ua

Testosterone hloov mus rau hauv dihydrotestosterone raws li kev ua ntawm {{{0}}reductase, thiab dihydrotestosterone tuaj yeem txhawb kev loj hlob thiab kev loj hlob ntawm prostate. 5 -reductase muaj ob hom subtypes, uas yog hom I isoenzyme thiab hom II isoenzyme. Hom I isoenzyme muaj kev ua me nyuam, thiab hom II isoenzyme koom nrog kev hloov pauv ntawm testosterone hauv daim tawv nqaij thiab daim siab. Cov khoom no yog ib qho tshwj xeeb 5 -reductase inhibitor. Nws inhibits hom I thiab hom II 5 -reductase isoenzymes los ntawm kev tsim cov enzyme complex, inhibits kev hloov ntawm testosterone rau hauv dihydrotestosterone (DHT), thiab ces inhibits zus tau tej cov androgen dihydrotestosterone, yog li inhibiting kev loj hlob ntawm prostate nyob rau hauv cov neeg mob. benign prostatic hyperplasia (BPH). 0.5 mg ib hnub twg, tom qab 1 mus rau 2 lub lis piam ntawm cov tshuaj, cov txiaj ntsig ntawm cov khoom no ntawm kev txo DHT nce mus txog qhov siab tshaj plaws, thiab cov ntshav DHT tuaj yeem txo los ntawm 85% mus rau 90%. Cov neeg mob nrog prostates loj noj 5 mg ib hnub twg, thiab DHT txo qis hauv 12 lub lis piam.

Pharmacokinetics

Cov tshuaj no tau nqus sai sai ntawm qhov ncauj, nrog rau bioavailability txog 60%. Tom qab kev tswj hwm qhov ncauj ntawm 0.5 mg, cov tshuaj ntshav siab nce mus txog qhov siab tshaj plaws hauv 2 mus rau 3 teev. Thaum noj nrog zaub mov, qhov siab tshaj plaws concentration (Cmax) txo los ntawm 10% mus rau 15%. Cov tshuaj muaj qhov ntim ntawm 300 mus rau 500 L, plasma protein khi tus nqi txog li 99%, thiab ib qho 1-acid glycoprotein khi tus nqi ntawm 96.6%. Cov tshuaj concentration hauv cov phev ntawm cov neeg noj qab haus huv tuaj yeem pab dawb yog 3.4 ng / ml, uas zoo ib yam li hauv plasma. Cov tshuaj plasma concentration nce mus txog lub xeev khov kho tom qab siv cov tshuaj no tas li rau 6 lub hlis. Cov tshuaj no feem ntau metabolized los ntawm hepatic cytochrome CYP3A4 thiab feem ntau yog tawm hauv cov quav, ntawm 5% yog cov tshuaj uas tsis muaj metabolized, 40% yog cov metabolites, thiab tsawg dua 1% yog cov tshuaj uas tsis muaj metabolized hauv cov zis. Kev tshem tawm ib nrab-lub neej ntawm cov tshuaj no yog kwv yees li 5 lub lis piam [2].

Dutasteride zoo li cas rau cov plaub hau poob?

Yog li, dutasteride zoo npaum li cas thaum siv los ua kev kho mob rau cov plaub hau poob?

Thaum muab piv rau finasteride, Pimstone hais tias dutasteride yog qhov muaj zog ntau dua inhibitor ntawm 5-AR enzyme thiab li no muaj zog ntau dua hauv kev txo qis DHT.

Tshwj xeeb, nws hais tias thaum siv cov tshuaj pleev ib ce, dutasteride tuaj yeem muaj cov txiaj ntsig zoo hauv kev kho mob vim nws xa cov tshuaj ntau dua rau lub hom phiaj ntawm cov plaub hau follicle.

"Ib tug xov tooj ntawm kev tswj kom zoo thiab kev soj ntsuam soj ntsuam kev tshawb fawb tau tam sim no qhia meej cov txiaj ntsig ntawm dutasteride tshaj finasteride," Pimstone surmises. "Cov txiaj ntsig kho mob ntawm dutasteride tshwm sim los ntawm nws cov txiaj ntsig zoo ntawm 5-AR enzyme thiab DHT."

Hauv ib qho meta-analysisTrusted Source tau ua nyob rau xyoo 2019, dutasteride tau pom qhov nce ntxiv ntawm tag nrho cov plaub hau suav piv nrog finasteride.

Lub caij no, cov txiaj ntsig ntawm kev tshawb nrhiav cov placebo-tswj cov kev ntseeg siab ntawm dutasteride piv rau finasteride, pom tias yav dhau los tau ua haujlwm zoo dua hauv kev nce lub hom phiaj ntawm cov plaub hau suav.

Thaum muaj qee qhov kev tshawb fawb txhawb nqa cov txiaj ntsig ntawm dutasteride rau cov plaub hau poob, nws yuav yog qhov zoo tshaj plaws los tswj koj cov kev cia siab.

Siv dutasteride tuaj yeem yog ib qho cuab yeej zoo rau kev txwv cov plaub hau, tab sis cov kws tshaj lij hais kom nco ntsoov tias nws yuav tsis loj hlob plaub hau.

Txawm li cas los xij, muaj kev sib xyaw ua ke ntawm finasteride thiab minoxidil uas tau pom tias yog kev kho mob kom tsis txhob muaj plaub hau thiab txhawb kev loj hlob ntawm plaub hau tib lub sijhawm.

Dab tsi yog qhov txaus ntshai ntawm kev siv dutasteridekho cov plaub hau poob?

Raws li nrog rau txhua yam tshuaj, tshwj xeeb tshaj yog kev kho mob off-label, muaj kev pheej hmoo thiab kev phiv los xav txog.

Nws tseem ceeb heev uas yuav tsum nco ntsoov tias dutasteride tsis yog FDA pom zoo raws li kev kho plaub hau yog li koj yuav tsum tau siv kev ceev faj ntxiv yog siv nws rau lub hom phiaj no.

Qee qhov kev mob tshwm sim muaj xws li tawv nqaij thiab tawv nqaij khaus, hws txias, thiab kiv taub hau.

"Qee zaum, koj tuaj yeem ntsib kev nyuaj siab, mob hauv siab, o, kev sib deev tsis zoo, thiab xav tua tus kheej," Abdullah hais.

Txawm li cas los xij, Pimstone ntseeg hais tias cov tshuaj pleev ib ce - muab cov khoom xyaw siv nyob rau hauv ntau qhov chaw uas lawv paub tias muaj kev nyab xeeb - yuav tsum muaj kev nyab xeeb siv, "raws li cov ntaub ntawv tshuaj pleev ib ce feem ntau xa cov dutasteride tsawg dua rau hauv cov kab mob ntau dua li cov ntawv hauv qhov ncauj."

Nws kuj tau sau tseg tias qhov ncauj thiab tshuaj pleev xim dutasteride rau txiv neej qauv plaub hau poob tau kawm kho mob rau ntau xyoo.

"Nrog rau qhov kev kho mob dav dav no, peb tsis paub txog qhov tsis zoo tshwm sim uas tau hais txog kev pheej hmoo tseem ceeb nrog cov qauv ntawm qhov ncauj," nws xaus lus.

Lwm txoj hauv kev zoo los tiv thaiv thiab kho cov plaub hau poob

Dutasteride (Avodart) nyab xeeb npaum li cas?

1. Dutasteride feem ntau yuav ua rau cov phev txo qis, thiab qhov no yuav kav ntev heev. Txawm tias tom qab tso tseg cov tshuaj, qhov txo qis hauv cov phev suav yuav txuas ntxiv mus ntev. Dutasteride puas ua rau muaj menyuam tsis taus? Tsis muaj qhov xaus hauv US FDA daim ntawv tshaj tawm. Hais txog kev txo qis kev sib deev, qhov tshwm sim yog siab dua li ntawm 1 mg ntawm Finasteride.
2. Tsis tas li ntawd, vim tias muaj ntau hom 1 5 -reductase receptors nyob rau hauv lub hlwb, nws tsis paub tias yuav ua li cas mus sij hawm ntev Dutasteride yuav muaj rau lub hlwb tom qab noj nws. Finasteride tsis tshua muaj txiaj ntsig vim nws tshwj xeeb inhibits hom 2 5 -reductase.
3. US Food and Drug Administration (FDA) tam sim no tau tso cai siv Dutasteride rau cov neeg laus uas muaj prostate hypertrophy. Yog li, yog tias koj muaj hnub nyoog tshaj 50 xyoo thiab muaj teeb meem plaub hau, kev siv Dutasteride (Avodart) tuaj yeem txiav txim siab.
4. Daim ntawv tshaj tawm US FDA tau hais tias qhov ntau ntawm Dutasteride hauv cov qaub ncaug lossis cov phev ntawm cov txiv neej noj Dutasteride yuav tsis cuam tshuam rau kev loj hlob ntawm lub embryo. Txawm li cas los xij, cov poj niam cev xeeb tub yuav tsum tsis txhob kov cov tshuaj Dutasteride tawg kom tsis txhob nqus los ntawm daim tawv nqaij thiab ua rau fetal malformations.

Peb Qhov Zoo

1.Quality: txhua yam khoom raug soj ntsuam nruj me ntsis los ntawm peb cov neeg ua haujlwm tshaj lij thiab tau txais daim ntawv pov thawj ISO.
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4.Perfect Reshipping txoj cai tau ua los tiv thaiv cov neeg siv khoom max txiaj ntsig thiab txo cov peev txheej poob.
5.Kev pab cuam tom qab muag zoo: ib txwm ua raws li cov xwm txheej ntawm koj cov pob khoom kom txog rau thaum xa thiab sim peb lub siab tshaj plaws los daws cov neeg siv khoom teeb meem entounered
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