Hmoov Procaine

Kev piav qhia

Procaine yog ib qho tshuaj loog hauv zos ntawm cov amino ester pawg. Nws yog siv feem ntau los txo qhov mob ntawm kev txhaj tshuaj intramuscular ntawm penicillin, thiab nws kuj yog siv hauv kev kho hniav. Raws li qhov chaw ntawm lub npe lag luam Novocain, hauv qee thaj tsam procaine raug xa mus rau generic li novocaine. Nws ua feem ntau yog sodium channel blocker. Niaj hnub no nws yog siv los kho nyob rau hauv qee lub teb chaws vim nws sympatholytic, anti-inflammatory, perfusion enhancing, thiab mus ob peb vas los txhim kho cov teebmeem.

Procaine tau tsim thawj zaug hauv xyoo 1905, tsis ntev tom qab amylocaine. Nws tau tsim los ntawm German chemist Alfred Einhorn uas tau muab cov tshuaj ua lag luam lub npe Novocaine, los ntawm Latin nov- (lub ntsiab lus tshiab) thiab -caine, ib qho kev xaus rau alkaloids siv los ua tshuaj loog. Nws tau qhia txog kev siv tshuaj kho mob los ntawm kws phais neeg Heinrich Braun. Ua ntej kev tshawb pom ntawm amylocaine thiab procaine, cocaine yog qhov siv tshuaj loog hauv zos tshaj plaws. Einhorn xav kom nws qhov kev tshawb pom tshiab los siv rau kev txiav, tab sis cov kws phais neeg nyiam siv tshuaj loog. Cov kws kho hniav, txawm li cas los xij, pom tias muaj txiaj ntsig zoo.

Procaine Pharmacology

Procaine hydrochloride ua rau cov hlab ntsha peripheral los tsim kev cuam tshuam kev cuam tshuam. Nws tso siab rau cov concentration gradients kom nkag mus rau hauv cov paj hlwb hauv cov hlab ntsha hauv qhov sib txawv, thaiv cov sodium ion channels nyob rau sab hauv, nce qhov kev zoo siab ntawm cov paj hlwb thiab poob excitability thiab conductivity. Cov ntaub ntawv xa tawm raug thaiv. Procaine hydrochloride muaj kev cuam tshuam zoo rau cov paj hlwb ntau dua li cov hlab ntsha ntawm lub cev, thiab ntawm cov fibers me dua cov fibers loj. Procaine hydrochloride kuj muaj antiarrhythmic, anticonvulsant, anti-inflammatory thiab coronary artery dilation los.

Nws tsis tshua muaj tshuaj lom thiab yog ib qho ntawm cov tshuaj loog siv hauv zos. Cov tshuaj no yog ib tug luv luv-acting ester lub zos tshuaj loog nrog tsawg lipophilicity thiab tsis muaj zog nkag mus rau hauv mucous daim nyias nyias. Feem ntau tsis siv rau tshuaj loog tshuaj loog, hauv zos txhaj tshuaj feem ntau yog siv rau infiltration anesthesia, conduction anesthesia, subarachnoid anesthesia thiab epidural anesthesia. Nws yuav siv sijhawm 1-3 feeb tom qab txhaj tshuaj thiab tuaj yeem kav ntev li 30-45 feeb.

Lub sijhawm txij nkawm tuaj yeem txuas ntxiv los ntawm 20% tom qab ntxiv epinephrine. Procaine tuaj yeem hydrolyzed los ntawm esterase hauv ntshav thiab hloov mus rau hauv para-aminobenzoic acid (PABA) thiab diethylaminoethanol. Cov qub tuaj yeem tiv thaiv cov kab mob tua kab mob ntawm cov tshuaj sulfa, yog li nws yuav tsum tsis txhob siv ua ke nrog sulfa tshuaj. Procaine kuj tseem siv tau rau kev sib khi hauv zos ntawm cov chaw raug mob. Kev noj tshuaj ntau dhau tuaj yeem ua rau lub hauv nruab nrab lub paj hlwb thiab cov hlab plawv. Qee lub sij hawm nws tuaj yeem ua rau muaj kev tsis haum tshuaj, yog li kev kuaj tawv nqaij ua xua yuav tsum tau ua ua ntej noj cov tshuaj, tab sis cov neeg uas muaj qhov tsis zoo ntawm daim tawv nqaij tuaj yeem muaj kev tsis haum tshuaj. Cov neeg uas ua xua rau cov tshuaj no tuaj yeem siv chloroprocaine thiab lidocaine hloov.

Procaine Pharmacokinetic

Procaine hydrochloride feem ntau yog hydrolyzed los ntawm lub siab mus rau p-aminobenzoic acid thiab diethylamine hauv lub cev. Qhov qub yog ua ke nrog glycine thiab tawm hauv cov zis, thiab tom kawg yog acetylated lossis methylated thiab tawm hauv cov zis. Kev tshem tawm ib nrab ntawm lub neej ntawm procaine hydrochloride yog 1.5 mus rau 2 teev, uas cuam tshuam los ntawm cov ntshav siab, lub siab ua haujlwm thiab cov ntshav plasma cholinesterase.

Procaine yog dab tsi?

Procaine yog ibtshuaj loog hauv zosfeem ntau siv raucov ntaub so ntswgThaum cov txheej txheem kho mob xws li kev kho hniav, kev phais me, lossis kev txhaj tshuaj. Nws ua haujlwm los ntawmthaiv cov hlab ntshanyob rau hauv qhov chaw uas nws tau thov, ib ntus tiv thaiv qhov hnov ​​ntawm qhov mob. Procaine tseem paub los ntawm lub npe nrovNovocain.

Nws belongs rau ib chav kawm ntawm cov tshuaj hu uaester-hom tshuaj loogthiab feem ntau yog siv rautshuaj loog hauv zoslos ua kom tus neeg mob tau yooj yim dua thaum cov txheej txheem kho mob luv luv. Procaine feem ntau tau hloov los ntawm cov tshuaj loog tshiab, tab sis nws tseem siv tau hauv qee qhov chaw.

Ntxiv rau nws cov khoom siv tshuaj loog, procaine kuj tau tshawb nrhiav rau lwm yam kev siv, xws li kev txhim kho cov ntshav ncig lossis kho mob xws li mob caj dab hauv qee yam kev siv tshuaj, txawm hais tias cov kev siv no tsis tshua muaj thiab tsis tau txais dav hauv cov tshuaj.

Procaine ua haujlwm li cas?

Procaine ua haujlwm los ntawmthaiv kev conduction ntawm paj hlwb impulses, tshwj xeeb tshaj yog cov cim mob, nyob rau hauv qhov chaw uas nws tau muab. Nws ua tiav qhov no los ntawm:

Inhibiting sodium channels: Procaine khi rau thiab thaiv cov kab hluav taws xob-gated sodium hauv cov paj hlwb, uas yog lub luag haujlwm rau tsim thiab xa hluav taws xob teeb liab (kev ua tau zoo). Los ntawm kev thaiv cov channel no, procaine tiv thaiv cov hlab ntsha los ntawm depolarizing, uas yog qhov tsim nyog rau kev xa cov teeb liab, suav nrog cov cim mob, mus rau lub hlwb.

Numbing cheeb tsam: Raws li cov hlab ntsha impulses raug thaiv, qhov kev hnov ​​​​mob thiab lwm yam kev xav xws li kov thiab qhov kub thiab txias tau ploj mus ib ntus lossis ploj tag rau hauv thaj chaw uas siv procaine.

Procaine feem ntau yog siv rautshuaj loog hauv zos, txhais tau hais tias nws tsuas yog cuam tshuam rau ib cheeb tsam ntawm lub cev yam tsis tau ua kom tsis nco qab. Nws cov nyhuv yog ib ntus, feem ntau nyob nruab nrab ntawm30 feeb mus rau 1 teevnyob ntawm qhov ntau npaum thiab cov txheej txheem tshwj xeeb.

Dosage thiab siv

Kev txhaj tshuaj hauv zos: Qhov kev txhaj tshuaj feem ntau yog 0.25%-0.5%, thiab qhov ntau npaum li cas nyob ntawm qhov xav tau ntawm tus mob, tab sis nws yuav tsum tsis pub tshaj 1.5g ib teev. Yog tias lub sijhawm tshuaj loog luv luv, ib qho me me ntawm cov tshuaj epinephrine (1; 1) tuaj yeem muab ntxiv los ua kom cov nyhuv ntev. Kev kho hniav qee zaum siv cov tshuaj loog ntawm 2% mus rau 4%.
Cov kev ceev faj
1. Thaum cov concentration ntau dhau los txhaj rau hauv cov hlab ntsha, nws tuaj yeem ua rau muaj kev ntxhov siab, tsis hnov ​​​​tsw, kiv taub hau, tsis meej pem, perioral hnov ​​​​qhov txawv txav, tinnitus, thiab tshee ntawm lub ntsej muag thiab sab ceg; Tom qab ntawd, tonic-clonic convulsions yuav tshwm sim. Thaum cov ntshav plasma concentration siab heev, nws tuaj yeem cuam tshuam ua pa thiab ua rau ua pa nres thiab
coma.

2. Kev noj ntau dhau yuav ua rau xeev siab, tawm hws, lub plawv dhia, ua pa nyuaj, ua pa tawm ntawm lub ntsej muag, delirium, zoo siab, thiab convulsions. Convulsions tuaj yeem cawm tau los ntawm kev txhaj tshuaj amobarbital.
3. Thaum lub sij hawm tus txha nraub qaum, cov ntshav siab feem ntau poob, uas tuaj yeem tiv thaiv tau los ntawm kev txhaj tshuaj intramuscular ntawm 15 mus rau 20 mg ntawm ephedrine ua ntej tshuaj loog.
4. Qee zaum anaphylactic shock tshwm sim, yog li tus neeg mob keeb kwm ua xua yuav tsum tau nug ua ntej siv tshuaj, thiab kev kuaj intradermal (intradermal txhaj ntawm 0.1ml ntawm 0.25% tshuaj) yuav tsum tau ua rau cov neeg mob nrog tsis haum raws cai.
5. Nws tsis haum rau kev sib xyaw nrog cov kua qab zib vim nws tuaj yeem txo nws cov tshuaj loog hauv zos.

Peb Qhov Zoo

1.Quality: txhua yam khoom raug soj ntsuam nruj me ntsis los ntawm peb cov neeg ua haujlwm tshaj lij thiab tau txais daim ntawv pov thawj ISO.
2.Price: qis dua peb cov phooj ywg vim peb yog lub Hoobkas. Ib qho luv nqi yuav muab thaum koj txiav txim loj.
3.Delivery: Peb muaj cov Tshuag txaus kom peb tuaj yeem ua tus xa tuaj hauv 24 teev tom qab them nyiaj.
4.Perfect Reshipping txoj cai tau ua los tiv thaiv cov neeg siv khoom max txiaj ntsig thiab txo cov peev txheej poob.
5.Kev pab cuam tom qab muag zoo: ib txwm ua raws li cov xwm txheej ntawm koj cov pob khoom kom txog rau thaum xa thiab sim peb lub siab tshaj plaws los daws cov neeg siv khoom teeb meem entounered
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