SARMs Hmoov GW501516 (Cardarine) / GSK-516 CAS 317318-70-0 Rau Cov Kev Rog Kom Rog Thiab Kev Kho Kom Zoo Dua

Khoom npe: GW-501516

Khoom lus:

Khoom npe: 2- (4 - ((2- (4- (Trifluoromethyl phenyl) -5-methylthiazol-4-yl) methylthio) -2-methylphenoxy) acetic acid
Cov Lus Txhais: 2- (4 - ((2- (4- (TRIFLUOROMETHYL PHENYL) -5-METHYLTHIAZOL-4-YL) METHYLTHIO) -2-METHYLPHENOXY) ACETIC ACID; 2- [2-Methyl-4 - [[[ 4-methyl-2- [4- (trifluoromethyl) phenyl] -5-thiazolyl] methyl] thio] phenoxy] acetic Acid; Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid; 2- (4 - ( 2- (4- (trifluoromethyl) phenyl) -4-methylthiazol-5-yl) methylthio) -2-methylphenoxy) acetic acid; GW 1516; 2- (2-methyl-4 - ((5-methyl-2- ( 4- (trifluoromethyl) phenyl) thiazol-4-yl) methylthio) phenoxy) acetic acid; GW501516, Free Acid; GSK-516
CAS: 317318-70-0
MF: C21H18F3NO3S2
MW: 453.5
Huv: 99%
Kev Thov Ua: Khoom Siv Tshuaj Dawb Khoom Dawb
Qeb: Qib Tshuaj Kws Tshuaj

Kev siv: Rau kev rog, mob ntshav qab zib, dyslipidemia thiab kab mob plawv
Kev sim tshuaj txhais tau hais tias tswj cov lipids thiab nce qib HDL, lossis cov roj (cholesterol) zoo nyob rau hauv cov ntshav. Lub xovtooj ntawm-permeable, thiazolyl compound uas ua haujlwm xws li kev muaj peev xwm, kev sib raug zoo, PPARδ agonist. Tso cov khoom xaiv xaiv rau PPARδ piv rau PPARα thiab PPARγ. Tsis txhob exibit ib qho kev ua tawm tsam lwm yam nuclear lossis non-nuclear receptors. Tshaj tawm tias ua rau cov roj av efflux thiab ABAC1 nthuav qhia hauv macrophages, fibroblasts, thiab lub plab hnyuv.

GW501516 Nqe lus piav qhia:

QHOV TSEEM CEEB: Tsis muaj rog, txhim kho kev ua siab ntev, tsis muaj kev phiv, lub cev tsim, kho cov rog rog ntxiv rau pab txhawb lub cev nqaij ntshiv, nce qhov nqaij mob.

Cardarine (GW-501516) tau sib sau ua ke nyob rau hauv qeb ntawm SARMS, txawm li cas los ntawm cov qauv thiab txhais tau, nws yog PPAR modulator. Raws li PPAR hloov kho, nws ua kom AMP-ua kom muaj protein ntau kinase thiab txhawb kev ua kom cov piam thaj hauv cov leeg pob txha mos. GW-501516 muaj cov peev xwm thim rov qab cov teeb meem metabolism los ntawm kev ua kom cov roj ntsha oxidation. Nws suav hais tias yog kev kho mob hnyav rau kev rog rog thiab lwm yam mob ntsig txog.

GW501516 yog lub npe ntawm Glaxo Wellcome cov tshuaj (GW sawv rau lub tuam txhab thiab tus naj npawb yog tus ntawm cov khoom lag luam). Kuj tseem hu ua GW-501,516, GW1516, GSK-516). Nws yog PPARδ receptor agonist uas tsis tau coj mus ntxiv dua li kev sim tshuaj. Xws li nws yog txwv tsis pub hauv kev ua si nawv. Nws haum rau ntau qhov chaw hauv daim ntawv teev npe, suav nrog tshwj xeeb "peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (piv txwv li GW501516)". Tab sis nws tseem yuav tuaj nyob rau hauv WADA qhov kev ntes tshiab txhua “cov tsis raug pom zoo tshuaj” ntu uas lub hom phiaj thim ib qho yeeb tshuaj tsis raug cai uas siv los ntawm cov kis las.

GW501516 (tseem hu ua GW-501,516, GW1516, GSK-516) yog PPAR& receptor agonist uas tau tsim los ntawm kev sib koom tes ntawm Ligand Pharmaceuticals thiab GlaxoSmithKline nyob rau xyoo 1990, tau nkag mus rau hauv kev txhim kho kev soj ntsuam raws li kev sib tw tshuaj rau cov kab mob metabolic thiab cov kab mob plawv, thiab tau tso tseg xyoo 2007 vim tias kuaj tsiaj txhu pom tias cov tshuaj ua rau mob qog noj ntshav sai sai hauv ntau lub plab hnyuv siab raum.

Hauv 2007 qhov kev tshawb fawb tau tshaj tawm tias cov koob tshuaj GW501516 tau muab ntau rau cov nas tsuag txhim kho lawv lub cev ua tau zoo; kev ua haujlwm tau dav dav sib tham hauv cov xov xwm nrov, thiab ua rau muaj kev lag luam dub rau cov neeg sib tw hauv tshuaj thiab rau nws txoj kev tsim txom los ntawm cov neeg ncaws pob ua tus neeg sawv cev.

GW501516Applications:

GW501516 tuaj yeem siv los ntawm cov neeg ncaws pob ua ib qho kev ua haujlwm ergogenic txhim kho cov tshuaj uas tsis tau tswj tam sim no los ntawm cov kev cai lossis kuaj pom los ntawm cov qauv ntsuas. Ib qho ntawm cov kws tshawb nrhiav tseem ceeb los ntawm txoj kev tshawb fawb txog kev txhim kho kev tiv thaiv kab mob kev tsim kho txoj kev kuaj zis kom paub cov tshuaj, thiab ua rau nws muaj rau International Pawg Neeg Tuav Haujlwm.
GW stimulates cov piam thaj kev txhim kho thiab cov leeg nqaij pob txha. Nws hlawv roj los ntawm kev ua kom muaj roj fatty acid oxidation. Nws' s pom tias yog ib qho kev kho mob rau kev rog vim nws' s muaj peev xwm ua kom sai li sai ntawm roj. Tsis tas li, Cardarine tau hais kom nce HDL los ntawm qhov nruab nrab ntawm 79% (cov roj cholesterol zoo) thiab txo qis LDL (cov roj (cholesterol) tsis zoo) hauv cov kev sim qib II tam sim no. GW 501516 yog PPARδ agonist. Cov kev pab no ua rau kom koj cov qib HDL nce siab los ntawm cov kev hais tawm, cov roj uas txhaws cov roj av ABCA1.

GW stimulates cov piam thaj kev txhim kho thiab cov leeg nqaij pob txha. Nws hlawv roj los ntawm kev ua kom muaj roj fatty acid oxidation. Nws tau pom tias yog kev kho mob ua rau kev rog rog vim tias nws muaj peev xwm sai roj ntau ntau. Tsis tas li, Cardarine tau hais kom nce HDL los ntawm qhov nruab nrab ntawm 79% (cov roj cholesterol zoo) thiab txo qis LDL (cov roj (cholesterol) tsis zoo) hauv cov kev sim qib II tam sim no. GW 501516 yog PPARδ agonist. Cov kev pab no ua rau kom koj cov qib HDL nce siab los ntawm cov kev hais tawm, cov roj uas txhaws cov roj av ABCA1.

GW501516Functions:

Ntau cov kev tshawb fawb tshawb fawb tau ua los ntawm cov nas nrog Cardarine (GW-501516) kev siv. GW yog xaiv agonist, lossis ua kom muaj zog, ntawm PPAR receptor. Kev khi ntawm GW-501516 mus rau PPAR nrhiav cov co ua kom muaj zog PGC-1a. PPAR / co activator complex tom qab tswj hwm kev qhia ntawm cov protein koom nrog kev siv hluav taws xob.

GW-501516 kuj tseem ua rau pom cov rog rog metabolism hauv cov leeg pob txha thiab tiv thaiv kev rog los ntawm kev noj zaub mov. Kev ntsuam xyuas ua rau cov rog rhesus liab ua pov thawj GW nce HDL (cov roj (cholesterol) zoo thiab txo qis VLDL (cov roj (cov roj) tsis zoo). GW tau tsim tawm thaum chiv thawj raug tsim los ua kev kho mob rau cov teeb meem roj cholesterol, uas nws tau pom tias muaj tus nqi siab ntawm kev ua tau zoo hauv kev ua.

GW50156 tswj hwm kev hlawv roj los ntawm ntau cov txheej txheem. Nws nce cov piam thaj kev nkag siab hauv cov pob txha cov leeg thiab nce cov leeg cov nqaij, tshwj xeeb tshaj yog cov noob koom nrog hauv kev nyiam lipid siv. Qhov kev hloov no hloov lub cev' s metabolism kom pom zoo ua rau cov rog ua rau lub zog tsis txhob siv cov roj carbohydrates lossis cov leeg nqaij, muaj peev xwm tso cai rau kev soj ntsuam cov neeg mob rog rog kom poob rog yam tsis muaj teeb meem nqaij catabolism lossis cuam tshuam thiab teeb meem satiety nrog ntshav qab zib tsawg Cov. GW-501516 kuj tseem nce cov leeg nqaij, uas txhim kho cov kua nplaum ua kom lub siab thiab txo cov rog rog tsawg txawm tias nyob hauv cov nas noj cov zaub mov muaj roj ntau, hais tias GW-501516 yuav muaj kev tiv thaiv kev rog.

Siv Siv Ncaws Pob:

Cardarine yog siv los ntawm cov kis las sib tw hauv ntau yam kis las sib tw. Piv txwv li, cov neeg ncaws pob thev naus laus zis tuaj yeem ua kom qhov kev tawm dag zog ntev dhau los ntawm kev tso cov PPAR no nrog cov tshuaj AMP analog AICAR, lossis khiav cardarine solo. Raws li qhov tshwm sim, lawv yuav muaj lub peev xwm ntau dua mus rau qhov siab dua RPM thaum lawv khiav yam tsis tau tsoo lub siab tshaj plaws. Qhov no yuav ua rau cov neeg khiav / caij / neeg ua luam dej los dag lawv lub siab tshaj plaws thiab mus ntev dua yam tsis muaj cua, ua rau cov tshooj no ua rau riam phom zoo kawg los siv rau hauv kev ua kis las. Qhov tseeb, dhau los ntawm kev paub ntawm tus kheej Kuv tuaj yeem qhia tau tias cardarine tuaj yeem khob 30-45 vib nas this so lub sijhawm 5K yog siv siv los sib tw.

GW501516 Ntau npaum:

GW-501516 coj qhov ncauj. Feem ntau kev noj tshuaj ntau rau qhov no PPAR-RA yog 10-15mg ib hnub rau 8 lub lis piam. Txawm li cas los xij, qee qhov ntawv tshaj tawm hais tias cov tshuaj yuav tsum tau siv rau 12 lub lis piam rau cov txiaj ntsig zoo tshaj plaws, nrog 20mg ib hnub twg raug pom zoo los ntawm cov neeg feem coob.

GW 501516 Qhov Teeb Meem:

Tsis txhob hais tias tsis muaj ib qho, tab sis 20 xyoo dhau los tsis pom muaj kev cuam tshuam tshwm sim los ntawm ib tug neeg twg kawm cov tshuaj no

GW501516 tsis tau tsuas yog raug sim hauv cov ncauj lus noj qab haus huv, tab sis kuj yog cov uas sim" lub neej tiag tiag" cov cwj pwm (xws li kev haus dej haus cawv, txhawb nqa cov tshuaj muaj yees, thiab kev siv cov khoom luam yeeb). Nws tsis paub tseeb yog tias muaj kev cuam tshuam ntev ntev, tab sis tsis muaj kev tshawb fawb tau luam tawm hais txog lwm yam.
Qhov no yog dab tsi ua rau Cardarine nrov heev li thiab siv tau ntev dhau lub sijhawm. Hauv qee qhov kev tshawb fawb, muaj txawm tias muaj cov cim qhia kev thim rov qab mob ntshav qab zib, rog, Dyslipidemia thiab ntau lwm yam kabmob.

1, Zoo zoo nrog cov nqi sib tw:
1) Txuj Ci: Asmeskas Txuj Ci
2) Txhua Purity≥99.8%
3) Peb yog cov chaw tsim khoom lag luam thiab tuaj yeem muab cov khoom lag luam zoo nrog nqe Hoobkas.