Sarms hmoov GW501516

Kev piav txog

GW501516, tseem hu ua Cardarine lossis Endurobol, yog ib qho kev siv tshuaj lom neeg uas tau tsim nyob rau xyoo 1990 uas yog qhov muaj peev xwm kho rau cov kab mob metabolic thiab cov kab mob plawv. Nws zwm rau cov chav kawm uas hu ua kev xaiv Androgen Receptor Modulators (sarms)

Dab tsi yog GW501516?
 

GW501516, tseem hu ua Cardarine lossis Endurobol, yog ib qho kev siv tshuaj lom neeg uas tau tsim nyob rau xyoo 1990 uas yog qhov muaj peev xwm kho rau cov kab mob metabolic thiab cov kab mob plawv. Nws zwm rau cov chav kawm uas hu ua kev xaiv Androgen Receptor Modulators (sarms)

GW501516 (tseem hu ua GW-501, 516, GW1516, cardarine li endero receporation ntawm Ligand Photo thiab GlaxosmithKline nyob rau xyoo 1990.

Nws tau pib tsim kho cov kab mob metabolic thiab cov kab mob plawv tab sis muaj cov txiaj ntsig zoo rau cov neeg ncaws pob thiab cov neeg ua haujlwm lub cev.

Nws yog cov xaiv agonist ntawm peroxisome proliferator -}} ushinged receptor delta. Nws txhais tau tias nws ua kom nws muaj nyob hauv lub cev, uas tuaj yeem cuam tshuam rau lub zog metabolism hauv txoj kev ua kom muaj kev tawm dag zog. Hauv cov ntsiab lus yooj yim, cov khoom no tuaj yeem pab txhim kho lub zog thiab kev ntxhov siab thaum lub sijhawm ua haujlwm.

Molecular architecture thiab kev siv tshuab: lub hnab ev ntawv eparenome

Tshuaj Kho Mob

Iupac Npe: 2-Methyl-4 - ((4-(4- (4- (4- (7- Thenyl) -1,3-Thiazol-5-YL) MethylsulfanyL) Phenoxyacetic Acid

● Cov mis molecular: C₂₁h₁₈f₃no₃s₂

● Molecular hnyav: 453.5 G / Mol

● Solubility: Lipophilic, xav tau lipid -}}} cov saw hlau triglycerides) rau kev nqus tau zoo.

Cov mechanistic Usnations

GW501516 Kev ua kom muaj Parpá ua rau lub ntsej muag zoo ntawm cov genomic thiab tsis - genomic cuam tshuam:

● Ehgigenetic reprogramming: Demethylates txhawb nqa ntawmPDK4thiabUa kom huv huv4, txhim kho fatty acid oxidation (fao) thiab lipid droplet hydrolysis.

● Circradian synchronization: ModulatesBMAL1 / MoosCov noob caj noob tswv, raws li cov kev ua ub no nrog cov kev ua kom zoo nkauj kom ua rau muaj zog ua kom muaj zog thaum lub sijhawm nquag ua haujlwm.

● Tsis - coding RNA: Upregulates Mir-107, uas suppressesHIF-1, txo cov glycolytic dependency under hypoxic mob.

Muaj qhov sib txawv

● Mitochondrial Remodeling: Induces cristae ntom nce ntawm 30-40%, txhim kho hluav taws xob thauj cov saw hlau equiciency.

● Mob - lier axis atxis: Txhawb Fiblighlight Kev Loj Hlob Zoo 21 (FGF21) kev tsim khoom, txuas daim di ncauj rau hepatic ketalesis.

● Ntshav Ntshav - bien bagier venetration: Ua kom muaj PARPARδ hauv astrocytes, txhawb kev neuroprotrectective ceramide metabolism.

Tsim qauv thiab synergistic nrhav

Teeb Meem Nruab Nrab Teeb

● GW501516 (10 mg AM) + Selisistat (5 mg PM): Combagic cov leeg ntoj ntas los ntawm pparΔ thiab sirtin-1 coactivation.

● GW 501516 + lub sij hawm -}} txwv pub mis: 8-teev noj lub qhov rai Amplifies circadian letabolic ib nrab.

Neuroprotecive Raws Cai

● GW501516 (15 mg) + Tsov ntxhuav yog mane extract (1g): Txhim kho BDNF thiab Cerebral Fao hauv kev raug mob hlwb lub hlwb kev puas tsuaj.

Pharmaconininetics thiab chrono - faib

Kev nqus: Tmax=3}} - 5 teev; Circadian variations nyob rau hauv bile acid ntws ntws hloov kho kev hloov pauv bioavailability los ntawm 15-20%.

● Ib Nrab - lub neej: 20-26 teev, nrog rau theem nrab ncov los ntawm Enterohepatic recirculation.

● Metabolism: Sulfotransferase 1e1 (sult1E1) COMPORTIONS INTEROCYTES, ua cov sulfates tsis muaj zog tshaj tawm.

● Polymorphism: Sult1E1 Cov Acetylators ceev yuav xav tau 25% kev tshuaj ntau dua rau kev ua tau zoo.

Post - Kev Kho Mob Dynamics thiab Mitigation

● Epigenetic nco: FAO noob nyob fypomethylated rau 6-8 lub lis piam pos- kev voj voog, txhawb nqa cov txiaj ntsig metabolic.

● Mitochondrial autophagy flux: Post {{{- Kev yoo mov (48 teev) Clears Mediochondized Mitochondres ua los ntawm Peppar PeparΔ Active.

● Vascular Surveillance: Txhua xyoo Carotid Intima -}} media dickness (CIMT) SCANS rau cov neeg siv ntau tshaj 6-hli kev siv.

Muab ntawm GW501516 Hmoov

1. Tshab Ntau Npaum:
Cov tshuaj pom zoo rauGW501516yog feem ntau ntawm10-20 mg ib hnubCov. Cov neeg siv feem ntau nrhiav tau10-15 mg ib hnubYuav kom ua tau zoo rau kev ua kom muaj roj ua kom muaj roj thiab kev nce qib kom tsis txhob paub txog yam tsis muaj kev phiv los.

2.Dosing sijhawm:
Vim nwsntev ib nrab ib nrab - lub neej(16-24 teev), GW501516 yog feem ntau noj ib zaug ib hnub. Nws tuaj yeem nqa tuaj txhua lub sijhawm ntawm hnub, txawm hais tias ntau tus neeg siv nyiam coj nwsThaum sawv ntxovlos yog ua ntej lawv workouts kom ua kom zoo rau qhov cuam tshuam ntawmnyiaj tauthiabrog rogCov. Nws tuaj yeem nqa nrog lossis tsis muaj khoom noj.

3.Txhua thiab npaj thiab npaj:
Txij li GW501516 hmoov yog cov tshuaj muaj zog heev, nws yog ib qho tseem ceeb kom ntsuas qhov ntsuas kom yog. Cov neeg siv feem ntau yuav tsum tau aPrecision Nplaikom hnyav tawm cov hmoov kom raug. Ib qho ntxiv, nws feem ntau yaj nyob rau hauv cov kua, xws li dej lossis dej caw, los pab txhawb kev noj haus yooj yim.

4.Cov ntev:
Feem ntau cov neeg siv xaiv rau6-8 lub lim tiam musnrog GW501516. Tom qab ua tiav lub voj voog, nws raug nquahu kom nqa akev sontawm tsawg kawg 4 lub lis piam kom tsis txhob txhim kho kev ua siab ntev rau qhov sib txuas. Qhov no yuav pab tswj nws cov hauj lwm zoo thiab tiv thaiv lub cev los ntawm kev yoog mus rau qhov sib xyaw ua ke.

Peb Qhov Zoo

1.Quality: Txhua yam khoom yog ntsuas nruj me ntsis los ntawm peb cov neeg ua haujlwm tshaj lij thiab tau txais ISO daim ntawv pov thawj.
2.Qhov: Ntau dua qis dua peb cov phooj ywg txij li peb yog Hoobkas. Ib qho luv nqi yuav muab thaum koj ua ib qho kev txiav txim loj.
3.Delivery: Peb muaj cov khoom lag luam txaus yog li peb tuaj yeem xa khoom xa hauv 24 teev tom qab them nyiaj.
4.peraFect resologchping txoj cai tau ua los tiv thaiv cov neeg siv khoom mount mount mount mess max thiab txo lub zog poob.
5.Txhua tom qab - muag kev pab: ib txwm khiav ntawm cov xwm txheej ntawm koj cov parcel kom txog thaum muab peb txoj kev hloov pauv cov neeg yuav khoom
6. Cov khoom lag luam nyoos: Cov tshuaj nyoos, tib neeg loj hlob lawm, semi-}}} ua tiav roj, sarms nyoos, anabolic steroids