Aicar CAS 2627-69-2 Nrog Tus Nqi Zoo

Kev piav qhia

AICAR, tseem hu ua 5-Aminoimidazole-4-carboxamide ribonucleotide, yog ib qho khoom siv hluavtaws uas tau txais kev pom zoo rau nws cov teebmeem ntawm kev tawm dag zog kev ua haujlwm thiab cov txheej txheem metabolic. Nws tsis yog SARM (Xaiv Androgen Receptor Modulator) zoo li Ostarine tab sis yog ib qho me me uas ua kom muaj enzyme hu ua AMP-activated protein kinase (AMPK). AMPK yog ib qho enzyme uas ua lub luag haujlwm tseem ceeb hauv kev tswj lub zog metabolism hauv cov hlwb. Thaum qhib, AMPK txhawb nqa cov txheej txheem uas txhim kho lub zog tsim khoom, xws li qabzib uptake thiab fatty acid oxidation. Qhov no tuaj yeem ua rau muaj kev mob siab ntxiv, txhim kho kev siv cov piam thaj, thiab txhim kho cov rog rog. AICAR tau kawm txog nws cov kev siv tshuaj kho mob hauv ntau yam mob ntsig txog cov metabolism, suav nrog ntshav qab zib, rog rog, thiab kab mob plawv. Nws kuj tau txais kev nyiam nyob rau hauv qhov kev ua si kis las vim nws muaj peev xwm txhim kho kev tawm dag zog thiab kev ua siab ntev hauv kev tshawb fawb tsiaj. Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias AICAR tsis raug pom zoo rau tib neeg siv los ntawm cov cai tswj hwm xws li US Food and Drug Administration (FDA). Kev tshawb fawb ntawm AICAR nyob rau hauv tib neeg yog txwv, thiab nws cov kev cuam tshuam mus sij hawm ntev, kev ruaj ntseg profile, thiab tej yam tshwm sim yuav tsis to taub tag nrho. Tsis tas li ntawd, nws tseem ceeb heev uas yuav tsum tau qhia tias kev siv AICAR lossis lwm yam kev ua tau zoo-txhim kho cov khoom hauv kev sib tw kis las yog suav tias yog doping thiab raug txwv los ntawm feem ntau cov koom haum kis las thiab cov koom haum tswj hwm.

Hauv Vitro

HepG2 hlwb raug kho nrog ntau qhov ntau ntawm AICAR (0.1-1.0 mM) rau 12, 24, thiab 48 h, raws li. Kev qhia theem ntawm IR- txo qis nrog 0.25, {{10}}.5, thiab 1.0 mM ntawm AICAR ntawm 48 h rau 50 feem pua, 53 feem pua, thiab 46 feem pua ​​​​ntawm cov tswj, raws.

Hauv Vivo

Kaum plaub lub lis piam txiv neej, lean (L; 31.3 g lub cev wt) cov tsiaj qus thiab ob / ob (O; 59.6 g lub cev wt) nas raug txhaj nrog AMP-activated kinase (AMPK) activator AICAR (A) ntawm { {8}}.5 mg/g ib hnub twg los yog kev tswj saline (C) rau 14 hnub. Thaum 24 teev tom qab txhaj tshuaj zaum kawg (nrog rau 12-h nrawm), txhua tus nas raug tua, thiab cov leeg nqaij (gastrocnemius, soleus, thiab plantaris) yog excised rau kev soj ntsuam. Cov leeg nqaij qis dua hauv OC (159 ± 12 mg) dua li LC, LA, thiab OA (176 ± 10, 178 ± 9, thiab 166 ± 16 mg, raws li) cov nas, ywj siab ntawm lub cev qhov hnyav.^[3].
Lub raum hnyav hnyav dua nyob rau hauv pab pawg tsis kho thaum piv nrog ob qho kev tawm dag zog thiab AICAR (0.5 mg / g lub cev wt) pawg. Lub plawv qhov hnyav yog siab dua nyob rau hauv pab pawg qoj ib ce ntau dua li lwm pab pawg, thaum lub siab hnyav hnyav dua hauv AICAR-kho pab pawg thaum piv nrog cov kev tawm dag zog thiab pab pawg tsis kho.

Yuav ua li cas mus txiav txim:

Ua ntej:Thov qhia rau kuv paub cov khoom koj tab tom nrhiav, kom muaj nuj nqis, thiab lub teb chaws qhov chaw.

Thib ob:Koj paub meej tag nrho cov ntsiab lus, thiab muab peb kev yuav khoom;

Thib peb:Peb xa tus nqi nthuav dav ntawm peb cov khoom thiab muab cov qauv tsim nyog rau kev siv.

Plaub:Koj lees paub qhov kev txiav txim thiab them nyiaj 100 feem pua ​​​​ua ntej thiab xa peb qhov chaw nyob kom ntxaws.

Thib tsib:Peb npaj cov khoom xa tuaj raws li koj xav tau.

Rau:Peb muab kev pab cuam tom qab muag tom qab koj tau txais parcel

Txhua yam kev xav tau, thov hu rau kuv
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