Kev piav qhia
SR9009 Stenabolic yog ib qho ntxiv uas tau siv dav los ntawm cov neeg ncaws pob thiab cov neeg txhawb zog rau nws cov txiaj ntsig ntau. Ib qho ntawm qhov zoo tshaj plaws ntawm cov tshuaj ntxiv no yog tias nws pab kom poob phaus los ntawm kev txhawb nqa cov metabolism, yog li ua kom yooj yim rau hlawv rog.
Ntxiv mus, SR9009 txhim kho kev ua siab ntev thiab lub zog, uas yog qhov zoo rau cov neeg ncaws pob uas yuav tsum tau ua ntawm lawv qhov siab tshaj thaum sib tw. Cov tshuaj ntxiv no kuj pab tswj cov ntshav qab zib thiab tuaj yeem txo qhov mob.
Lwm qhov txiaj ntsig ntawm SR9009 Stenabolic yog tias nws tuaj yeem txhim kho kev pw tsaug zog zoo. Kev so kom raug thiab rov qab zoo yog qhov tseem ceeb rau kev ua haujlwm ntawm lub cev kom zoo, thiab cov tshuaj ntxiv no tuaj yeem pab ua tiav cov qauv pw tsaug zog zoo dua.
Ntxiv rau cov txiaj ntsig no, qee qhov kev tshawb fawb qhia tias SR9009 tuaj yeem muaj kev tiv thaiv kev laus ntawm lub cev hlwb. Nws qhib cov protein Rev-ErbA, uas tswj cov kev ua ntawm tes muaj feem xyuam rau cov txheej txheem kev laus xws li DNA kho cov txheej txheem.
SR9009 Stenabolic muaj ntau yam txiaj ntsig kev noj qab haus huv uas ua rau nws yog qhov kev xaiv zoo nkauj rau cov neeg uas tab tom nrhiav kev txhim kho lawv lub cev thiab kev noj qab haus huv tag nrho.
Kev pheej hmoo ntawm SR9009 Stenabolic
Nws yog ib qho tseem ceeb kom nco ntsoov tias cov kev pheej hmoo muaj feem cuam tshuam nrog kev siv anabolic. Ib qho ntawm cov kev txhawj xeeb tseem ceeb yog qhov sib xyaw no tsis tau dhau los ntawm tib neeg kev sim siab, yog li peb tsis paub ntau txog nws cov teebmeem mus sij hawm ntev.
Lwm qhov kev pheej hmoo cuam tshuam nrog SR9009 Stenabolic yog tias nws tuaj yeem cuam tshuam rau daim siab ua haujlwm thaum koj noj cov tshuaj ntau. Nws tuaj yeem cuam tshuam tshwj xeeb rau cov neeg uas muaj lub siab ua ntej lossis cov neeg haus cawv tsis tu ncua.
Tsis tas li ntawd, vim tias SR9009 Stenabolic ua haujlwm los ntawm kev hloov cov noob qhia hauv cov hlwb, nws muaj peev xwm ua rau tsis muaj kev hloov pauv hauv DNA kev tswj hwm.
Thaum qee tus neeg qhia tias muaj zog thiab mob siab rau tom qab noj SR9009 Stenabolic, lwm tus muaj kev phiv xws li insomnia thiab ntxhov siab vim. Nws yog ib qho tseem ceeb kom mloog koj lub cev thiab tsis txhob siv cov tshuaj ntxiv yog tias koj pom tias muaj kev phiv tshwm sim. Nyeem ntxiv: RAD-140 SARMs (Testolone): Cov teebmeem tshwm sim, kev noj tshuaj thiab ua ntej thiab tom qab tau txais txiaj ntsig
Thaum SR9009 Stenabolic tuaj yeem muab qee yam txiaj ntsig rau cov neeg ncaws pob thiab cov kws tsim lub cev tab tom nrhiav kev txhim kho lawv cov kev ua tau zoo, nws yog ib qho tseem ceeb uas yuav tsum ntsuas cov txiaj ntsig zoo ntawm cov kev pheej hmoo ua ntej txiav txim siab seb puas yuav siv cov tshuaj ntxiv no.
hauv vitro kev tshawb fawb
SR9009 koob tshuaj-raws li nce kev qhia ntawm chimeric Gal4 DNA-binding domain (DBD)-REV-ERB ligand-binding domain (LBD) los yog Gal4- teb luciferase reporter noob (SR9009: REV-ERB IC{10 }} nM, REV-ERB IC50=800 nM). SR9009 muaj zog inhibits kev sau npe hauv kev sib koom ua ke kev sib txuas nrog kev siv tag nrho REV-ERB thiab cov neeg sau xov xwm luciferase uas tau tsav los ntawm Bmal1 txhawb nqa (IC{18}} nM). SR9009 inhibits BMAL1 mRNA qhia hauv HepG2 hlwb hauv REV-ERB / -dependent yam. Kev khi ncaj nraim ntawm SR9009 rau REV-ERB kuj tau lees paub tias siv kev ntsuas dichroism ncig (Kd=800 nM)
Hauv Vivo
SR9009 (100 mg / kg, ip)-kho nas tau pom qhov txo qis hauv adiposity ntau dua. Plasma non-esterified fatty acids (NEFA) thiab plasma qabzib (19 feem pua) kuj tau txo qis (23 feem pua) hauv SR9009- kho tsiaj. Hauv cov ntaub so ntswg adipose dawb (WAT), SR9009 kev kho mob ua rau txo qis ntawm cov noob encoding enzymes koom nrog hauv triglyceride (TG) synthesis, uas kuj tau pom hauv cov nas ntshiv.
kev sim ntawm tes
SR9009 yog yaj hauv DMSO thiab diluted nrog cov xov xwm tsim nyog[1]. HEK293 hlwb tau loj hlob nyob rau hauv 96- cov phiaj zoo (1 × 106 / qhov zoo) thiab tau hloov pauv hloov pauv siv lipofectamine. Cells raug hloov nrog tag nrho ntawm 200 ng ntawm DNA ib qhov dej uas muaj pGL4 mIL-17 firefly luciferase reporter tsim, lub pGL4 mIL{10}} ntxiv rau CNS-5 firefly luciferase reporter tsim, los yog pGL4 mIL-17 2kB RORE mutant (100 ng/well), tus actin promotr Renilla reniformis luciferase reporter (50 ng/well), thiab tswj vector ib leeg lossis kuaj DNA (tag nrho-ntev ROR lossis tag nrho-ntev ROR ntawm 50 ng / zoo). Tag nrho 48 tib neeg nuclear receptors yog sawv cev hauv qhov kev ntsuam xyuas tshwj xeeb thiab SR9009 raug kuaj ntawm qhov concentration ntawm 20 μM. Cov qauv ntawm qhov kev ntsuam xyuas yog ib qho kev ntsuam xyuas cotransfection nrog Gal4 DNA binding domain-nuclear receptor fusions hauv HEK293 hlwb
Peb qhov zoo:
1, Zoo siab nrog tus nqi sib tw:
1) Txuj: BP / USP / EP / Enterprise txuj
2) Tag nrho Purity Ntau dua lossis sib npaug li 99 feem pua
3) Peb yog cov chaw tsim khoom thiab tuaj yeem muab cov khoom lag luam zoo nrog lub Hoobkas nqi.
2, Kev xa khoom sai thiab nyab xeeb
1) Parcel tuaj yeem xa tawm hauv 24 teev tom qab them nyiaj
2) Kev ruaj ntseg thiab tsis pom kev xa khoom.Ntau yam kev thauj mus los rau koj xaiv.
3) Kev lis kev cai hla tus nqi Ntau dua lossis sib npaug li 99 feem pua
4) Peb muaj peb tus kheej tus neeg sawv cev / xa rov qab / tus neeg xa khoom tuaj yeem pab peb xa peb cov khoom sai thiab nyab xeeb,
thiab peb muaj Tshuag nyob rau ntawd rau kev hloov.
3, Peb muaj cov neeg siv khoom thoob plaws ntiaj teb.
1) Kev pabcuam tshaj lij thiab kev nplua nuj ua rau cov neeg siv khoom xav tau yooj yim, cov khoom tsim nyog thiab xa khoom sai raws li lawv lub siab nyiam.
2) Kev lag luam tawm tswv yim thiab cov khoom tawm tswv yim yuav raug qhuas, ua tau raws li cov neeg siv khoom xav tau yog peb lub luag haujlwm.
3) Zoo siab, tus nqi sib tw, xa khoom sai, kev pabcuam thawj zaug tau txais kev ntseeg siab thiab qhuas los ntawm cov neeg siv khoom
Txhua yam kev xav tau, thov hu rau kuv
Email: amyraws195@gmail.com
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Telegram: ntxiv rau 86-17507125642
Cim npe nrov: sr9009 cas 1379686-30-2 tus nqi siab, Tuam Tshoj sr9009 cas 1379686-30-2 tus nqi siab manufacturers, lwm tus neeg, Hoobkas
