Kev piav qhia
Trestolone yog ib qho hluavtaws androgen uas inhibits kev tso tawm ntawm follicle-stimulating hormone thiab impairs spermatogenesis. Luteinizing hormone kuj yog suppressed, uas txiav zus tau tej cov testosterone. Lub azoospermia thiab oligospermia yog thim rov qab tom qab txiav tawm ntawm trestolone. Trestolone muaj androgenic thiab anabolic zog thiab poob ntawm lwm yam kev sib deev yam ntxwv tsis pom. Zoo li Testosterone, trestolone nkag mus rau hauv lub zog aromatization rau cov tshuaj estrogen. Kev siv trestolone es tsis txhob siv testosterone rau androgen hloov kho yuav muaj kev noj qab haus huv los ntawm kev txo qhov tshwm sim ntawm tus kab mob prostate. Trestolone tau nyob rau theem II kev kuaj mob rau kev tswj andropause. Txawm li cas los xij, qhov kev txhim kho no tau txiav tawm.
Trestolone acetate yog ib qho hluavtaws los tiv thaiv kab mob qog noj ntshav uas tau pom tias inhibit qhov kev loj hlob ntawm cov qog nqaij hlav cancer hauv cov qauv tsiaj. Nws yog ib qho tshuaj estrogen receptor modulator uas khi rau cov tshuaj estrogen receptor thiab inhibits nws ua kom los ntawm estradiol. Trestolone acetate kuj tau pom tias inhibit zus tau tej cov inflammatory cytokines, xws li qog necrosis factor- (TNF- ) thiab interleukin -1 (IL-1), uas tej zaum yuav yog vim nws muaj peev xwm ua raws li. ib qho kev loj hlob zoo rau lub cev tiv thaiv kab mob. Trestolone acetate tuaj yeem siv los kho cov kab mob degenerative lossis kab mob hauv plab, xws li Crohn's disease. Cov tshuaj no kuj muaj txiaj ntsig zoo rau cov kab mob inflammatory, xws li IBD, thiab kab mob autoimmune, xws li mob caj dab rheumatoid. Qhov koob tshuaj zoo yog 10 mg / kg lub cev qhov hnyav hauv ib hnub muab qhov ncauj.
Sawv ntawm MENT - Trestalone
MENT (7alpha-methyl-19-nortestostrone), los yog trestolone yog ib qho ntawm ob peb 19-nortestosterone derivatives yuav tsum tau soj ntsuam raws li ib tug txiv neej txoj kev siv tshuaj tiv thaiv kab mob vim nws cov tshuaj lom neeg tshwj xeeb. Thaum pib, cov tuam txhab tshuaj tau muab cov tshuaj progesterone nrog testosterone txhawm rau tsim cov txiv neej txoj kev siv tshuaj tiv thaiv kab mob vim yog progesterone lub peev xwm los tua cov spermatogenesis.
Thaum testosterone tuaj yeem txo cov phev ntau lawm, koob tshuaj rau kev kuaj-tsuas yog kev tiv thaiv kev yug menyuam yuav siab dhau kom tsis txhob muaj kev phiv tshwm sim.
Testosterone tuaj yeem hloov mus rau DHT ntawm 5alpha-reductase, nws tuaj yeem muaj kev cuam tshuam rau cov prostate, nrog rau nce txiv neej tus qauv balding. Txij li thaum MENT tsis muaj peev xwm los khi rau 5alpha-reductase thiab yog li tsis tuaj yeem hloov mus rau DHT, nws ua rau nws yog ib tus neeg sib tw zoo tshaj plaws rau kev tiv thaiv txiv neej androgen.
Yog vim li cas rau qhov no yog nyob rau hauv lub cim alpha-methyl pawg ntawm carbon 7 ntawm lub molecule. Cov pab pawg methyl no sticks tawm hauv qab lub nplhaib steroidal thiab sterically inhibits kev hloov dua siab tshiab rau DHT. Txawm li cas los xij, MENT tseem tuaj yeem ua rau aromatization thiab dhau mus ua lwm yam androgen-dependent functions, ua kom nws ua tau zoo li testosterone hauv lub cev txawm tias yog ib qho 19-nortestosterone derivative. MENT kuj tau pom tias muaj kev sib raug zoo tsawg kawg nkaus rau cov progesterone thiab mineralocorticoid receptors, txawm tias yog ib qho nandrolone derivative.
Txhua yam kev xav tau, thov hu rau kuv
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