Follistatin 344 CAS 80449-31-6

Khoom Paub meej:

Cov tsos mob: Dawb mus rau dawb crystalline hmoov los yog pob

Kev hloov kho qhov muag tshwj xeeb (c{{{0}}}.5,10 feem pua ​​HAc):-50.0 ~-60.0 degree

Cov ntsiab lus dej (Karl Fischer): Tsawg dua lossis sib npaug rau 5.0 feem pua

Cov ntsiab lus Acetate (los ntawm HPLC): Tsawg dua lossis sib npaug rau 15.0 feem pua

Amino Acid Composition: ± 10 feem pua ​​​​ntawm kev xav

Purity (los ntawm HPLC): Ntau dua lossis sib npaug rau 98.0 feem pua

Ib qho Impurity (los ntawm HPLC): Tsawg dua lossis sib npaug rau 1.0 feem pua

Peptide Cov ntsiab lus (los ntawm feem pua ​​N): Ntau dua lossis sib npaug li 80 feem pua

Assay(Los ntawm Anhydrous, Acetic Acid-dawb) :95.0~105.0 feem pua

Cov kab mob Endotoxins: Tsawg dua lossis sib npaug rau 5EU / mg

Follistatin yog cov protein uas ntxim nyiam uas tuaj yeem ua rau cov leeg nqaij ntau dhau los ntawm kev muaj peev xwm los ntawm kev txo qis myostatin. Cov kws tshawb fawb thawj zaug txheeb xyuas follistatin thaum kuaj cov porcine (re: npua) cov kua follicular hauv zes qe menyuam.

Nqe lus piav qhia:

Follistatin tseem hu ua activin-binding protein yog cov protein uas nyob rau hauv tib neeg yog encoded los ntawm FST noob. Follistatin yog ib qho autocrine glycoprotein uas tau nthuav tawm nyob rau hauv yuav luag txhua cov ntaub so ntswg ntawm cov tsiaj siab dua.Nws lub luag haujlwm tseem ceeb yog kev khi thiab bioeutralization ntawm cov tswv cuab ntawm TGF- superfamily, nrog rau kev tsom mus rau activin, paracrine hormone. Follistatin yog ib txwm pom nyob rau hauv cov leeg pob txha ntawm yuav luag txhua tus tsiaj nrog cov yam ntxwv siab lossis tsim, xws li tib neeg, nas, thiab nyuj. Follistatin yog siab nyob rau hauv cov amino acid cystine tsis tseem ceeb, tab sis tsis zoo li feem ntau cov proteins uas tau tham hauv lub ntiaj teb kev qoj ib ce, follistatin muaj cov carbohydrates txuas rau nws. Follistatin ua haujlwm los ntawm kev khi rau thiab inhibiting kev loj hlob ntawm kev loj hlob - (TGF- ) peptides xws li myostatin uas yog lub luag haujlwm rau kev tswj thiab txo cov leeg nqaij. Nws tseem tsim nyog taw qhia tias myostatin tuaj yeem muaj lub luag haujlwm tswj hwm hauv pob txha pob txha fibrosis; Myostatin ntau dhau tuaj yeem ua rau cov ntaub so ntswg ua haujlwm tsis zoo thiab ua rau muaj kab mob ntev hauv cov kabmob tseem ceeb, cov ntaub so ntswg, thiab cov pob txha pob txha.

ACE-031 yog ib qho fusion fusion protein uas tau pom tias ua kom cov leeg nqaij thiab lub zog hauv kev tshawb fawb tshawb fawb. ACE-031 tab tom kawm raws li kev kho mob rau cov kab mob metabolic, lub raum neoplasms ntawm menyuam yaus, mob plawv anomalies, muaj hnub nyoog txog cov nqaij ntshiv, thiab kev kho mob qog noj ntshav cuam tshuam txog cov leeg nqaij thiab cov kab mob neuromuscular. ACE-031 yog kev kho mob biologic, raws li activin receptor hom IIB (ActRIIB). Cov molecule inhibits signaling ntawm ActRIIB receptor khi thiab ua kom cov leeg nqaij thiab lub zog. ACE-031 yog ib qho recombinant fusion protein uas yog tsim los ntawm fusion ntawm tus qauv tshuaj tiv thaiv thiab ib feem ntawm ActRIIB receptor. Cov recombinant fusion protein tshem tawm myostatin thiab lwm yam biomolecules uas txwv cov leeg nqaij lossis kev loj hlob.
Follistatin 344 / FST yog thawj zaug pom tias yog follicle-stimulating hormone inhibiting tshuaj pom nyob rau hauv zes qe menyuam follicular kua. FST yog qhov muaj txiaj ntsig zoo ntawm activin binding protein uas tuaj yeem ua raws li cov tshuaj tiv thaiv activin. Ob txoj kev hloov pauv follistatin mRNAs muaj nyob, encoding mature FS nrog 288 amino acid residues (FS-288) thiab 315 aa residues (FS-315). Ntuj FS purified los ntawm porcine zes qe menyuam yog feem ntau yog carboxy-terminal truncated daim ntawv ntawm FS-315 muaj li ntawm 300 aa residues.
Follistatin 344 / FST tau txais txiaj ntsig sai sai hauv lub zej zog tsim lub cev raws li qhov muaj peev xwm ntxiv rau kom ceev cov ntaub so ntswg loj. Lwm cov protein, cov noob ntsig txog follistatin ua rau txoj hauv kev zoo ib yam li FST hais txog nws cov leeg nqaij. Cov nqaij ntshiv ntau ntxiv tuaj yeem ua rau lub cev tsim kom muaj txiaj ntsig zoo hauv qhov chaw sib tw.
FST yog ib qho kab mob gonadal protein uas tshwj xeeb inhibits follicle stimulating hormone tso tawm. Ib qho FST gene encodes ob isoforms Follistatin 317 thiab Follistatin 344 uas muaj 317 thiab 344 amino acids feem, uas ua los ntawm lwm txoj kev sib txuas ntawm precursor mRNA. Muaj pov thawj txuas polycystic zes qe menyuam syndrome thiab follistatin. Follistatin khi ncaj qha rau activin thiab ua haujlwm raws li cov tshuaj tiv thaiv activin. Nws tshwj xeeb inhibitor ntawm biosynthesis thiab tso tawm ntawm pituitary follicle stimulating hormone. Subunit : Monomer Subcellular Qhov Chaw : Secreted. Cov ntaub so ntswg tshwj xeeb: Isoform 1 yog qhov tseem ceeb tshaj plaws isoform hauv cov ntshav tab sis tsis tuaj yeem kuaj pom hauv cov kua follicular.

Daim ntawv thov:

ACE-031 yog ib qho fusion protein uas yog soluble thiab paub tias muaj lub tswv yim zoo hauv kev ua kom cov leeg nqaij muaj zog thiab loj. Cov polypeptide yog nyob rau hauv kev tshawb fawb rau kev kho mob ntawm ntau yam mob thiab cov kab mob xws li cov kab mob metabolic, mob plawv anomalies, lub raum neoplasms thaum yau, mob qog noj ntshav, hnub nyoog cuam tshuam cov leeg nqaij thiab lwm yam kab mob neuromuscular. ACE-031 yog biopeptide uas muaj cov khoom kho mob uas feem ntau yog raws li activin receptor hom 2 lossis ActRIIB. Cov polypeptide inhibits cell signaling los ntawm thaiv ActRIIB receptor yog li ua kom cov leeg muaj zog thiab loj. Nws yog ib qho khoom siv hluavtaws polypeptide ntawm cov tshuaj tiv thaiv ntuj thiab ib feem ntawm ActRIIB receptor. Thaum recombinant thev naus laus zis yog siv los fuse cov proteins, nws tshem tawm myostatin thiab lwm yam biomolecules uas txwv cov leeg nqaij thiab lub zog. ACE-031 raug cais raws li qeb ntawm cov proteins hauv TGF-beta super tsev neeg, uas yog qhov tseem ceeb hauv kev tswj cov leeg nqaij thiab lub zog. ACE-031 mechanism ntawm kev txiav txim yog los ntawm kev hloov pauv thiab nce kev tswj hwm ntawm cov leeg nqaij, kev tshawb fawb sim qhia tias polypeptide ua los ntawm inhibiting ActRIIB receptor thiab txhawb kev sib txawv ntawm myoblasts, kev loj hlob, thiab kev loj hlob. Raws li kev tshawb fawb kev tswj hwm ntawm ACE-031 rau 2 lub lis piam ua rau cov leeg pob txha ceev, nce qib adiponectin thiab txo cov qib leptin hauv lub cev. Lub polypeptide yog tsim los ntawm 368 amino acids nyob rau hauv ib theem zuj zus; Qhov no ua rau ib qho loj heev thiab complex polypeptide. Cov nqaij ntshiv yog qhov tseem ceeb los ntawm kev tsim cov leeg nqaij thiab qhov no tshwm sim ntawm cov amino acids thiab lwm yam tseem ceeb. TGF beta protein super tsev neeg, uas yog lub ntsiab regulator nyob rau hauv lub switching rau thiab tawm ntawm cov nqaij ntshiv los ntawm cov amino acids. Thaum ActRIIB receptors cuam tshuam nrog GDF-8, nws ua rau lub teeb liab hloov pauv uas ua rau kev pib ntawm myoblasts sib txawv, kev loj hlob thiab kev loj hlob. ACE-031 yog cov protein nyob rau hauv kev tshawb fawb los txhim kho cov leeg nqaij sib txawv hauv kev sib xyaw ua ke yog qhov tseem ceeb hauv inhibiting yam uas txwv cov leeg nqaij loj hlob thiab tsim cov myoblasts los ntawm endogenous khi rau cov hlwb. Qhov thaiv ntawm cov antagonist ua rau muaj kev txhim kho ntawm myoblasts, cov leeg ua haujlwm thiab txhim kho cov leeg nqaij. Cov txheej txheem tuaj yeem ua pov thawj tias yog qhov tseem ceeb hauv kev daws teeb meem xws li cov leeg nqaij dystrophy, androgen deprivation, thiab cov leeg tsis muaj feem cuam tshuam nrog corticosteroids ntawm lwm yam mob. Tsis zoo li cov tiam ntawm kev hloov pauv tshwj xeeb ribonucleotide raws li kev kho mob, kev kho mob rau Duchene leeg nqaij dystrophy lossis feem ntau hu ua DMD, ACE-031 tuaj yeem muaj txiaj ntsig zoo vim nws tsis cuam tshuam los ntawm kev hloov pauv uas twb muaj lawm.

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Cim npe nrov: follistatin 344 cas 80449-31-6, Tuam Tshoj, tuam ntxhab, lwm tus muag khoom, Hoobkas, nqe sau, hauv Tshuag, dawb qauv