Cov lus piav qhia ntxaws ntxaws
| Khoom npe: | Exemestane | CAS: | 107868-30-4 |
|---|---|---|---|
| Qhov tsos: | Dawb hmoov | Kev siv: | Muscle nce |
| Shipping Method: | EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC | Synonym: | Aromasin |
| Lub teeb siab: | tshuaj tiv thaiv estrogen,anti estrogen khoom | ||
Ceev kom meej
| Khoom npe | Exemestane |
| Lwm lub npe | Aromasin |
| CAS npe | 107868-30-4 |
| Cov mis mos molecular | C20H24O2 |
| Molecular hnyav | 296.4 |
| Molecular qauv |  |
| Melting point | 193 degree |
| Kev sib hloov kho qhov muag tshwj xeeb | ntxiv rau 290.2 degree |
| Assay | 99 feem pua |
Exemestane Acatate COA
KEV KAWM NTAWV | SPECIFICATION | TSEEM CEEB |
| Kev piav qhia | Dawb Crystalline hmoov | Dawb hmoov |
| Kev txheeb xyuas | Qhov zoo | Qhov zoo |
| Assay (los ntawm HPLC) | 98.0~102.0 feem pua | 98,64 :ua |
| Absorbance (E1cm) | 465~495 | 482.5 |
| Melting Point | 191-195 ° C | 193.5 ~ 195 0 degree |
| Poob Thaum Qhuav | 0.5 feem pua max | 0.19 feem pua |
| Kev sib hloov tshwj xeeb | ntxiv 288 degree ~ ntxiv 298 degree | ntxiv rau 290.2 degree |
| Residue ntawm Ignition | 0.1 feem pua max | 0.03 feem pua |
| Yam khoom muaj feem | Tag nrho: 1.5 feem pua max | <1.3% |
| Residue Solvents | 0.2 feem pua max | 0.10 feem pua |
| Hnyav Hlau | 20 ppm max | <10PPm |
| Xaus | Cov specification ua raws li tus qauv kev lag luam. | |
Kev piav qhia
Exemestane yog qhov ncauj steroidal aromatase inhibitor uas yog siv hauv ER-zoo mob qog noj ntshav ntawm lub mis ntxiv rau kev phais thiab / lossis hluav taws xob hauv cov poj niam tom qab yug menyuam.
Lub hauv paus ntsiab lus ntawm estrogen yog cov zes qe menyuam hauv cov poj niam premenopausal, thaum cov poj niam tom qab yug me nyuam feem ntau ntawm lub cev estrogen yog tsim los ntawm kev hloov pauv ntawm androgens rau hauv cov tshuaj estrogen los ntawm aromatase enzyme nyob rau hauv cov ntaub so ntswg peripheral (xws li cov ntaub so ntswg adipose zoo li lub mis). thiab ntau qhov chaw hauv lub hlwb. Estrogen yog tsim hauv zos los ntawm kev ua ntawm aromatase enzyme nyob rau hauv cov ntaub so ntswg peripheral uas nws ua hauv zos. Txhua yam tshuaj estrogen nyob rau hauv cov poj niam tom qab menopausal thiab cov txiv neej yog qhov tshwm sim ntawm cov tshuaj estrogen khiav hauv zos metabolism thiab nkag mus rau hauv lub cev.
Daim ntawv thov
Muaj ntau cov qog nqaij hlav hauv lub mis yog txhawb kom loj hlob los ntawm poj niam txiv neej cov tshuaj hormones estrogen thiab progesterone. Cov qog nqaij hlav hauv lub mis no yog hu ua hormone rhiab lossis hormone receptor zoo thiab tuaj yeem kho nrog cov tshuaj uas thaiv cov teebmeem ntawm cov tshuaj hormones.
Hauv cov poj niam uas tau muaj lawv lub cev tsis muaj zog, estrogen feem ntau yog tsim los ntawm kev hloov androgens (cov tshuaj hormones poj niam txiv neej ua los ntawm cov qog adrenal) rau hauv estrogens. Cov txheej txheem no yog hu ua aromatisation thiab tshwm sim feem ntau hauv cov nqaijrog, nqaij thiab daim tawv nqaij. Nws xav tau ib qho enzyme hu ua aromatase.
Exemestane thaiv cov txheej txheem ntawm aromatisation. Yog li nws txo qis cov tshuaj estrogen hauv lub cev. Hauv kev mob qog noj ntshav thaum ntxov, kev noj tshuaj exemestane tuaj yeem pab kom tsis txhob mob qog noj ntshav ntawm lub mis rov qab los. Hauv kev mob qog noj ntshav siab siab, cov qog nqaij hlav cancer tuaj yeem loj hlob qeeb lossis tsis loj hlob tag nrho.
Kev noj tshuaj
Qhov no yog nyob ntawm tus neeg thiab, kuj, tus nqi ntawm aromatizing compounds tus neeg khiav. Feem ntau, koob tshuaj pib zoo yog 12.5mg ED (txhua hnub) lossis 25mg EOD (txhua hnub). Tus neeg siv yuav tsum siv cov ntshav ua haujlwm kom pom tias lawv lub cev ua haujlwm li cas ntawm qhov pib noj lawv xaiv thiab tom qab ntawd kho raws li qhov xav tau. Cov neeg siv tshuaj anabolic steroid feem ntau yuav pom cov koob tshuaj uas lawv nyiam thiab lo rau nws yam tsis muaj teeb meem. Raws li kuv tau hais lawm, yog tias koj pib pom cov teeb meem sib koom ua ke ces cov koob tshuaj yuav tsum tau qis dua; ntawm qhov tod tes, yog tias koj pib pom cov tshuaj estrogen muaj feem xyuam nrog, xws li puffy lossis rhiab lub mis lossis dej tuav, nws yog lub sijhawm los ua kom ntau npaum li cas.
Cov txiaj ntsig ntawm Exemestane
>>>Kev tsim lub cev
Steroidal Exemestane inhibitor uas ua los ntawm kev txo qis cov tshuaj estrogen tsim los ntawm lub cev. Nws ua haujlwm los ntawm kev txwv kev hloov pauv ntawm Testosterone rau hauv cov tshuaj estrogen thiab qhov nruab nrab ntawm cov tshuaj estrogen yog 85 feem pua. Cov tshuaj kuj txo cov qib estradiol li ntawm 50 feem pua, nrog rau kev txiav txim siab nce qib testosterone.
Exemestane inhibitor uas ua haujlwm los ntawm inhibiting synthesis ntawm estrogen. Nws muaj txiaj ntsig zoo ntawm kev nce qib Testosterone thiab IGF hauv lub cev. Cov tshuaj kuj tseem muaj txiaj ntsig zoo thaum lub sijhawm kev kho mob tom qab lub voj voog thaum ib tus tab tom sim kho cov qib Testosterone ntuj kom tsis txhob muaj kev sib tsoo tom qab.
>>>Anti-estrogen tshuaj
Tau lees paub tias yog ib qho ntawm cov tshuaj kim tshaj plaws, Exemestane yog ib qho tshuaj tiv thaiv zoo tshaj plaws uas yog siv los ntawm cov ncaws pob thiab cov kws tsim lub cev. Kev kho mob cov tshuaj feem ntau yog muab rau kev kho mob cancer ntawm lub mis. Feem ntau hu ua Selective Estrogen Receptor Modulator (SERM), nws tau siv ua ntej rau kev tiv thaiv gynocomastia.
Txhua yam kev xav tau, thov hu rau kuv
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